机构：[1]Laboratory of Molecular and Translational Medicine, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, People’s Republic of China[2]Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Chengdu, Sichuan 610041, People’s Republic of China[3]Department of Thyroid and Breast Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, People’s Republic of China四川大学华西医院[4]Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, People’s Republic of China
The aim of this study was to evaluate whether an insertion/deletion polymorphism (rs3783553) locating in the miR-122 target gene IL1A 3' untranslated region was related to the risk of papillary thyroid carcinoma (PTC). Genomic DNA was extracted from peripheral venous blood of 273 patients with PTC and 509 controls. The IL1A rs3783553 polymorphism was genotyped by using a polymerase chain reaction assay. No significant difference of the distribution of the IL1A rs3783553 polymorphism was observed between PTC patients and controls. However, patients carrying the IL1A rs3783553 ins/ins genotype and ins allele had significantly decreased risks for developing T3 and T4 when compared with patients carrying the IL1A rs3783553 del/del genotype and del allele (ins/ins vs. del/del: OR = 0.22, 95% confidence interval (CI), 0.09-0.54; ins vs. del: OR = 0.58, 95% CI, 0.41-0.83, respectively). These results suggest that the rs3783553 polymorphism may be used as a genetic marker to predict the size/extension of PTC.
基金：
This work was supported by grants from the Special Research Foundation of Doctoral Priority to the Development of
Field Project (no. 20110181130013), National Natural Science Foundation of China (no. 81302149), Distinguished Young Scientist of Sichuan
University (no. 2013SCU04A38), the Science & Technology Pillar Program of Sichuan Province (14ZC1838), and the Ph.D. Programs Foundation of Ministry of Education of China (no. 20130181120011).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类|3 区医学
小类|4 区肿瘤学
最新[2023]版：
无
第一作者：
第一作者机构：[1]Laboratory of Molecular and Translational Medicine, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, People’s Republic of China[2]Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Chengdu, Sichuan 610041, People’s Republic of China
共同第一作者：
通讯作者：
通讯机构：[1]Laboratory of Molecular and Translational Medicine, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, People’s Republic of China[2]Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Chengdu, Sichuan 610041, People’s Republic of China
推荐引用方式(GB/T 7714)：
Gao Linbo,Zhu Xinxin,Li Zhihui,et al.Association between a functional insertion/deletion polymorphism in IL1A gene and risk of papillary thyroid carcinoma.[J].Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.2014,35(4):3861-5.doi:10.1007/s13277-013-1512-6.
APA：
Gao Linbo,Zhu Xinxin,Li Zhihui,Li Lijuan,Wang Tao...&Zhang Lin.(2014).Association between a functional insertion/deletion polymorphism in IL1A gene and risk of papillary thyroid carcinoma..Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine,35,(4)
MLA：
Gao Linbo,et al."Association between a functional insertion/deletion polymorphism in IL1A gene and risk of papillary thyroid carcinoma.".Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 35..4(2014):3861-5
