机构：[1]State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University and Collaborative Innovation Center of Biotherapy Chengdu P. R. China.四川大学华西医院[2]Department of Neurosurgery West China Hospital Sichuan University Chengdu P. R. China.四川大学华西医院[3]School of Materials Science and Engineering Sichuan University Chengdu Sichuan 610065 P. R. China.[4]Department of Nanoengineering Institute of Engineering in Medicine 245B SME Building MC 0448 University of California San Diego 9500 Gilman Drive La Jolla CA 92093 USA.[5]Department of Biomedical Engineering Tsinghua University School of Medicine Beijing P. R. China.[6]State key laboratory for manufacturing systems engineering Xi'an Jiaotong University Xi'an 710049 China.
Gene therapy has great promise for glioblastoma treatment; however, it remains a great challenge to efficiently deliver genes to the brain. The incomplete resection of glioblastoma always leads to poor prognosis. Here, a 3D-engineered conformal implant for eradicating the postsurgery residual glioblastoma is designed. This implant is constructed by 3D-printing technology to match the tumor cavity and release an oncolytic virus-inspired DNA nanocomplex to kill glioblastoma cells through apoptosis induction. Meanwhile, a 3D-engineered subcutaneous glioblastoma xenograft is built to mimic the resection tumor cavity in mice. Insertion of the implant into the glioblastoma resection cavity efficiently delays tumor recurrence and significantly prolongs overall survival. This study provides a proof-of-concept of glioblastoma therapy using a conformal implant that releases oncolytic DNA nanocomplexs. This strategy can lead to the development of future precision therapy for eradicating postsurgery residual tumors.
基金：
This work was supported
by the National Natural Science Foundation (81422025 and 81572990),
the Sichuan Province Youth Science and Technology Fund (2016JQ0020),
Sichuan province science and technology support plan (2015FZ0040,
2015SZ0049 and 0040205301F10), and the Outstanding Youth Fund of
Sichuan University (2014SCU04A12).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|1 区工程技术
小类|2 区化学综合2 区材料科学：综合2 区纳米科技
最新[2023]版：
大类|1 区材料科学
小类|1 区化学：综合1 区材料科学：综合2 区纳米科技
第一作者：
第一作者机构：[1]State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University and Collaborative Innovation Center of Biotherapy Chengdu P. R. China.[2]Department of Neurosurgery West China Hospital Sichuan University Chengdu P. R. China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Yang Yuan,Du Ting,Zhang Jiumeng,et al.A 3D-Engineered Conformal Implant Releases DNA Nanocomplexs for Eradicating the Postsurgery Residual Glioblastoma.[J].Advanced science (Weinheim, Baden-Wurttemberg, Germany).2017,4(8):1600491.doi:10.1002/advs.201600491.
APA：
Yang Yuan,Du Ting,Zhang Jiumeng,Kang Tianyi,Luo Li...&Gou Maling.(2017).A 3D-Engineered Conformal Implant Releases DNA Nanocomplexs for Eradicating the Postsurgery Residual Glioblastoma..Advanced science (Weinheim, Baden-Wurttemberg, Germany),4,(8)
MLA：
Yang Yuan,et al."A 3D-Engineered Conformal Implant Releases DNA Nanocomplexs for Eradicating the Postsurgery Residual Glioblastoma.".Advanced science (Weinheim, Baden-Wurttemberg, Germany) 4..8(2017):1600491
工程技术