机构：[1]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, P. R. China[2]Department of Neurosurgery, West China Hospital Sichuan University, Chengdu, P. R. China[3]School of Materials Science and Engineering, Sichuan University, Chengdu, Sichuan 610065, P. R. China[4]Department of Nanoengineering, Institute of Engineering in Medicine, 245B SME Building[5]University of California, San Diego 9500 Gilman Drive, La Jolla, CA 92093, USA[6]Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing, P. R. China[7]State key laboratory for manufacturing systems engineering, Xi’an Jiaotong University, Xi’an 710049, China
Gene therapy has great promise for glioblastoma treatment; however, it remains a great challenge to efficiently deliver genes to the brain. The incomplete resection of glioblastoma always leads to poor prognosis. Here, a 3D-engineered conformal implant for eradicating the postsurgery residual glioblastoma is designed. This implant is constructed by 3D-printing technology to match the tumor cavity and release an oncolytic virus-inspired DNA nanocomplex to kill glioblastoma cells through apoptosis induction. Meanwhile, a 3D-engineered subcutaneous glioblastoma xenograft is built to mimic the resection tumor cavity in mice. Insertion of the implant into the glioblastoma resection cavity efficiently delays tumor recurrence and significantly prolongs overall survival. This study provides a proof-of-concept of glioblastoma therapy using a conformal implant that releases oncolytic DNA nanocomplexs. This strategy can lead to the development of future precision therapy for eradicating postsurgery residual tumors.
基金：
National Natural Science FoundationNational Natural Science Foundation of China [81422025, 81572990]; Sichuan Province Youth Science and Technology Fund [2016JQ0020]; Sichuan province science and technology support plan [2015FZ0040, 2015SZ0049, 0040205301F10]; Outstanding Youth Fund of Sichuan University [2014SCU04A12]
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|1 区工程技术
小类|2 区化学综合2 区材料科学：综合2 区纳米科技
最新[2023]版：
大类|1 区材料科学
小类|1 区化学：综合1 区材料科学：综合2 区纳米科技
第一作者：
第一作者机构：[1]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, P. R. China[2]Department of Neurosurgery, West China Hospital Sichuan University, Chengdu, P. R. China
共同第一作者：
通讯作者：
通讯机构：[1]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, P. R. China[2]Department of Neurosurgery, West China Hospital Sichuan University, Chengdu, P. R. China
推荐引用方式(GB/T 7714)：
Yuan Yang,Ting Du,Jiumeng Zhang,et al.A 3D-Engineered Conformal Implant Releases DNA Nanocomplexs for Eradicating the Postsurgery Residual Glioblastoma.[J].ADVANCED SCIENCE.2017,4(8):1600491.doi:10.1002/advs.201600491.
APA：
Yuan Yang,Ting Du,Jiumeng Zhang,Tianyi Kang,Li Luo...&Maling Gou.(2017).A 3D-Engineered Conformal Implant Releases DNA Nanocomplexs for Eradicating the Postsurgery Residual Glioblastoma..ADVANCED SCIENCE,4,(8)
MLA：
Yuan Yang,et al."A 3D-Engineered Conformal Implant Releases DNA Nanocomplexs for Eradicating the Postsurgery Residual Glioblastoma.".ADVANCED SCIENCE 4..8(2017):1600491
工程技术