机构：[1]School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China[2]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, China四川大学华西医院[3]Institute of Traditional Chinese Medicine & Natural Products, Jinan University, Guangzhou, China
Three new phenolic glycosides, intermedia A-C (1-3), one new acyclic alcohol glycoside, intermedia D (4), together with 3 known glycosides (5-7), were isolated from the dried roots of Paeonia intermedia C. A. Meyer. Their structures were established by means of extensive spectroscopic analysis (HRESIMS, NMR). Compound 1 have a rare benzo[1,5]dioxepine skeleton. The bioassay results showed that compound 3 exhibited inhibitory activity against proinflammatory cytokines nitric oxide (NO) secretion in LPS-activated RAW264.7 cells with an IC50 value of 85.76 ± 1.36 μM.
基金：
National Natural Science Foundation of China (Grant No.
81603275) and the China Postdoctoral Science Foundation (Grant No. 2016M602697, No.
2018T110988).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类|3 区化学
小类|3 区应用化学3 区药物化学
最新[2023]版：
大类|3 区化学
小类|3 区应用化学4 区药物化学
第一作者：
第一作者机构：[1]School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China
共同第一作者：
通讯作者：
通讯机构：[1]School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China[3]Institute of Traditional Chinese Medicine & Natural Products, Jinan University, Guangzhou, China
推荐引用方式(GB/T 7714)：
Yu Liang,Zhu Ling-Juan,Wang An-Hua,et al.Anti-inflammatory glycosides from the roots of Paeonia intermedia C. A. Meyer.[J].Natural product research.2021,35(9):1452-1458.doi:10.1080/14786419.2019.1655020.
APA：
Yu Liang,Zhu Ling-Juan,Wang An-Hua,Qin Yu,Zhang Xue...&Yao Xin-Sheng.(2021).Anti-inflammatory glycosides from the roots of Paeonia intermedia C. A. Meyer..Natural product research,35,(9)
MLA：
Yu Liang,et al."Anti-inflammatory glycosides from the roots of Paeonia intermedia C. A. Meyer.".Natural product research 35..9(2021):1452-1458
