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Bioactive steroidal alkaloids from the fruits of Solanum nigrum.

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资源类型：
Pubmed体系：
作者：
Gu Xin-Yue[1,2] ; Shen Xiao-Fei[3] ; Wang Lun[1,2,*1] ; Wu Zhou-Wei[2] ; Li Fu[1,2] ; Chen Bin[2] ; Zhang Guo-Lin[2] ; Wang Ming-Kui[1,2,*1] ;
机构： [1]School of Pharmacy and Bioengineering, Chengdu University, Chengdu, 610106, China [2]Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization and Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, China [3]Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), Department of Paediatrics, West China Second University Hospital, Sichuan University, Chengdu, 610041, China
出处：
DOI： 10.1016/j.phytochem.2017.12.020
ISSN：

关键词： Solanum nigrum Linn Steroidal alkaloids Anti-inflammatory activity Cytotoxic activity

摘要：
The investigation of the fruits of Solanum nigrum led to the isolation of four previously undescribed steroidal alkaloids, named solanine A, 7α-OH khasianine, 7α-OH solamargine and 7α-OH solasonine, together with six known ones. The structures of the isolated compounds were elucidated unambiguously by spectroscopic data analyses and chemical methods. Solanine A represents an unusual steroidal alkaloid with an unprecedented 6/5/6/5/5/6 hexacyclic ring system, and its structure was confirmed by X-ray single crystal diffraction analysis. Compounds 2-4 were rare naturally occurring steroidal alkaloid glycosides bearing a hydroxyl group at C-7 position. Solanine A showed the most potent inhibitory activity against the LPS-induced NO production in murine RAW264.7 macrophages with an IC50 value of 3.85 ± 0.71 μM and significant cytotoxicity against MGC803, HepG2 and SW480 cancer cell lines with IC50 values of 6.00 ± 0.52 μM, 9.25 ± 0.49 μM and 6.23 ± 0.26 μM, respectively. Copyright © 2018 Elsevier Ltd. All rights reserved.

基金：
National Natural Science Foundation of China (No. 21561142003), West Light Foundation of Chinese Academy of Sciences (Y7C1031100) and Health and Family Planning Commission of Sichuan Province (17PJ485).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类 | 3 区 生物
小类 | 2 区 植物科学 3 区 生化与分子生物学
最新[2023]版：
大类 | 2 区 生物学
小类 | 2 区 生化与分子生物学 2 区 植物科学
第一作者：
第一作者机构： [1]School of Pharmacy and Bioengineering, Chengdu University, Chengdu, 610106, China [2]Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization and Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, China
共同第一作者：
通讯作者：
通讯机构： [1]School of Pharmacy and Bioengineering, Chengdu University, Chengdu, 610106, China [2]Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization and Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, China [*1]School of Pharmacy and Bioengineering, Chengdu University, Chengdu, 610106, China
推荐引用方式(GB/T 7714)：
Gu Xin-Yue,Shen Xiao-Fei,Wang Lun,et al.Bioactive steroidal alkaloids from the fruits of Solanum nigrum.[J].Phytochemistry.2018,147:125-131.doi:10.1016/j.phytochem.2017.12.020.
APA：
Gu Xin-Yue,Shen Xiao-Fei,Wang Lun,Wu Zhou-Wei,Li Fu...&Wang Ming-Kui.(2018).Bioactive steroidal alkaloids from the fruits of Solanum nigrum..Phytochemistry,147,
MLA：
Gu Xin-Yue,et al."Bioactive steroidal alkaloids from the fruits of Solanum nigrum.".Phytochemistry 147.(2018):125-131

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