机构：[1]Department of Otolaryngology, Head and Neck Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China.重庆医科大学附属第一医院[2]Department of Otolaryngology, Head and Neck Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.[3]Department of Cardio-Thoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China.重庆医科大学附属第一医院[4]Department of Pathology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.[5]Department of Biochemistry, Institute for Cancer Research, School of Preclinical Medical Sciences, Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.
Epithelial cell transforming sequence 2 (ECT2) is a guanine nucleotide exchange factor and its expression is associated with the development of malignant tumor types. However, to the best of our knowledge, there is no information on the role of ECT2 in the development and progression of laryngeal squamous cell carcinoma (LSCC). The present study aimed at investigating the expression pattern and potential role of ECT2 in the development and progression of LSCC. The expression of ECT2 in 81 pairs of LSCC and adjacent non-tumor tissues was characterized by immunohistochemistry and reverse transcription-quantitative polymerase chain reaction. ECT2 expression was upregulated in LSCC tissues and associated significantly with poor differentiation, higher stages, lymph node metastasis and poor survival in the sample population. The relative expression levels of ECT2 mRNA transcripts were correlated with the intensity of anti-ECT2 staining in 25 ECT2+LSCC specimens selected randomly. These results indicated that ECT2 expression was crucial for the progression of LSCC and may serve as a biomarker for the diagnosis and prognosis of LSCC.
第一作者机构：[1]Department of Otolaryngology, Head and Neck Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China.[2]Department of Otolaryngology, Head and Neck Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.
通讯作者：
通讯机构：[1]Department of Otolaryngology, Head and Neck Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China.[*1]Department of Otolaryngology, Head and Neck Surgery, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Chongqing 400016, P.R. China
推荐引用方式(GB/T 7714)：
Zhu Lin,Qin Gang,Ye Lin,et al.Epithelial cell transforming sequence 2 expression is associated with the progression of laryngeal squamous cell carcinoma.[J].ONCOLOGY LETTERS.2019,17(6):5699-5704.doi:10.3892/ol.2019.10226.
APA：
Zhu Lin,Qin Gang,Ye Lin,Jiang Li-Zhu,Zhou Tie-Jun...&Chen Hong-Yan.(2019).Epithelial cell transforming sequence 2 expression is associated with the progression of laryngeal squamous cell carcinoma..ONCOLOGY LETTERS,17,(6)
MLA：
Zhu Lin,et al."Epithelial cell transforming sequence 2 expression is associated with the progression of laryngeal squamous cell carcinoma.".ONCOLOGY LETTERS 17..6(2019):5699-5704
