The emerging roles of microRNAs (miRs) have been deeply investigated in cancer. However, the role of miR-194 in human laryngeal squamous cell carcinoma (LSCC) is still unclear. Here, we have demonstrated that miR-194 is significantly downregulated in LSCC tissues and cells, and overexpression of miR-194 inhibits the proliferation, migration, invasion, and drug resistance in LSCC cells. Moreover, Wee1 is identified as a novel direct target of miR-194. Ectopic expression of Wee1 at least in part overcomes the suppressive impacts of miR-194 on the malignant phenotypes of LSCC. Overall, our study provides new sights into the role of miR-194/Wee1 axis in LSCC and suggests a novel miR-194/Wee1-based clinical application for LSCC patients.
基金：
Chinese National Natural Science FoundationNational Natural Science Foundation of China [8161101021, 31271444, 81201726]; Guangdong Natural Science Funds for Distinguished Young Scholar [2014A030306001, 2014A030313057]; Guangdong Special Support Program for Young Talent [2015TQ01R350]; Science and Technology Program of Guangdong [2016A050502027, 2013B021800088]; Foundation for Research Cultivation and Innovation of Jinan University [21616119]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|2 区医学
小类|2 区血液学2 区肿瘤学
最新[2023]版：
大类|1 区医学
小类|1 区血液学1 区肿瘤学
第一作者：
第一作者机构：[1]Sun Yat Sen Univ, Affiliated Hosp 3, Dept Otolaryngol Head & Neck Surg, Guangzhou, Guangdong, Peoples R China;
通讯作者：
通讯机构：[1]Sun Yat Sen Univ, Affiliated Hosp 3, Dept Otolaryngol Head & Neck Surg, Guangzhou, Guangdong, Peoples R China;[2]Jinan Univ, Coll Life Sci & Technol, Guangdong Prov Key Lab Bioengn Med, Natl Engn Res Ctr Genet Med,Dept Cell Biol, Guangzhou, Guangdong, Peoples R China;[3]Jinan Univ, Coll Life Sci & Technol, Guangdong Prov Key Lab Bioengn Med, Natl Engn Res Ctr Genet Med,Inst Biomed, Guangzhou, Guangdong, Peoples R China;
推荐引用方式(GB/T 7714)：
Li Pei,Yang Yang,Liu Hui,et al.MiR-194 functions as a tumor suppressor in laryngeal squamous cell carcinoma by targeting Wee1[J].JOURNAL OF HEMATOLOGY & ONCOLOGY.2017,10(1):-.doi:10.1186/s13045-017-0402-6.
APA：
Li, Pei,Yang, Yang,Liu, Hui,Yang, An-Kui,Di, Jin-Ming...&Ye, Jin.(2017).MiR-194 functions as a tumor suppressor in laryngeal squamous cell carcinoma by targeting Wee1.JOURNAL OF HEMATOLOGY & ONCOLOGY,10,(1)
MLA：
Li, Pei,et al."MiR-194 functions as a tumor suppressor in laryngeal squamous cell carcinoma by targeting Wee1".JOURNAL OF HEMATOLOGY & ONCOLOGY 10..1(2017):-
医学