机构：[1]Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, PR China 四川大学华西医院[2]Institute of Digestive Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, PR China 四川大学华西医院[3]Department of Clinical & Experimental Medicine, Division of Oncology, Faculty of Health Sciences, Linko¨ ping University, Linko¨ ping, Sweden
Aim: To investigate the association and prognostic value of ANKZF1 gene for survival in colorectal cancer, the mechanism of ANKZF1 level alteration and correlated signaling pathways ANKZF1 is involved. Patients & methods: The Cancer Genome Atlas COREAD dataset was analyzed by bioinformatical investigation. Results: High ANKZF1 expression is associated with poor overall survival (hazard ratio [HR]: 2.094; 95% CI: 1.188-3.689; p = 0.011) and recurrence-free survival (HR: 1.762; 95% CI: 1.021-3.042; p = 0.042) in colon cancer. Bioinformatical analysis showed ANKZF1 was upregulated by amplification and exon expression. ANKZF1 was associated with angiogenesis and cancer signaling pathways. Conclusion: High ANKZF1 is an independent factor of poor survival (overall survival and recurrence-free survival) in colon cancer by taking part in angiogenesis and some cancer signaling pathways.
基金：
Natural Science Foundation of China (no. 81402446, to CW Fan), Research Foundation of Health and Family Planning Commission of Sichuan Province (no. 150136, to CW Fan).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|4 区医学
小类|4 区肿瘤学
最新[2023]版：
大类|4 区医学
小类|4 区肿瘤学
第一作者：
第一作者机构：[1]Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, PR China
共同第一作者：
通讯作者：
通讯机构：[1]Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, PR China [2]Institute of Digestive Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, PR China [3]Department of Clinical & Experimental Medicine, Division of Oncology, Faculty of Health Sciences, Linko¨ ping University, Linko¨ ping, Sweden
推荐引用方式(GB/T 7714)：
Zhou Xin,Shang Yan-Na,Lu Ran,et al.High ANKZF1 expression is associated with poor overall survival and recurrence-free survival in colon cancer.[J].Future oncology (London, England).2019,15(18):2093-2106.doi:10.2217/fon-2018-0920.
APA：
Zhou Xin,Shang Yan-Na,Lu Ran,Fan Chuan-Wen&Mo Xian-Ming.(2019).High ANKZF1 expression is associated with poor overall survival and recurrence-free survival in colon cancer..Future oncology (London, England),15,(18)
MLA：
Zhou Xin,et al."High ANKZF1 expression is associated with poor overall survival and recurrence-free survival in colon cancer.".Future oncology (London, England) 15..18(2019):2093-2106
