机构：[1]Department of General Surgery & Institute of Digestive Surgery and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, No.37 Guo Xue Xiang St., 610041 Chengdu, Sichuan Province, China四川大学华西医院
There was no literature reporting the relationship between AKAP13 and colorectal carcinoma. This study is aim to investigate the expression and role of AKAP13 in human colorectal cancers. This study investigated 94 pair-matched human colorectal cancers and adjacent normal mucosa, as well as 36 adenomas, of which mRNA expression of AKAP13 was detected by relative Quantitative-Real-Time RT-PCR and protein expression by immunohistochemical staining. AKAP13 gene was upregulated in colorectal cancer group by 2.259 times compared to control group without significant difference (P = 0.081), and no expression was detected in adenoma by RT-PCR. The positive expression rate of AKAP13 protein in colorectal carcinoma (52.3%) was significantly higher than those in adenoma (9.1%) and normal tissue (34.7%) (P = 0.006) by immunohistochemical staining. Either the mRNA or protein expressions of AKAP13 were correlated with histological types and differentiation grade (P < 0.05). Our results suggest AKAP13 protein may be related to the carcinogenesis of human colorectal cancer. However, more deeply and larger scale research are required to prove the correlation.
基金：
National Natural Science Foundation of China (No. 30600591) and China Medical
Board of New York Inc. (No. CMB 96636).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2010]版：
大类|4 区医学
小类|4 区医学：研究与实验
最新[2023]版：
大类|4 区医学
小类|4 区医学：研究与实验
第一作者：
第一作者机构：[1]Department of General Surgery & Institute of Digestive Surgery and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, No.37 Guo Xue Xiang St., 610041 Chengdu, Sichuan Province, China
通讯作者：
推荐引用方式(GB/T 7714)：
Hu Jian-Kun,Wang Ling,Li Yuan,et al.The mRNA and protein expression of A-kinase anchor proteins 13 in human colorectal cancer.[J].Clinical and experimental medicine.2010,10(1):41-9.doi:10.1007/s10238-009-0065-x.
APA：
Hu Jian-Kun,Wang Ling,Li Yuan,Yang Kun,Zhang Peng...&Zhou Zong-Guang.(2010).The mRNA and protein expression of A-kinase anchor proteins 13 in human colorectal cancer..Clinical and experimental medicine,10,(1)
MLA：
Hu Jian-Kun,et al."The mRNA and protein expression of A-kinase anchor proteins 13 in human colorectal cancer.".Clinical and experimental medicine 10..1(2010):41-9
