机构：[1]State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, University of Chinese Academy of Sciences, Beijing, 100101, China[2]School of Basic Medical Sciences of Southwest Medical University, Luzhou, 646000, Sichuan, China[3]Integrated Laboratory of TCM and Western Medicine, Peking University First Hospital, Xicheng District, Beijing, 100034, China[4]The Department of Biomedical Sciences in Imperial College London, UK
Formaldehyde is toxic and has been implicated in the pathologies of various diseases, such as cognitive impairment and cancer. Though d-ribose is widely studied and provided as a supplement to food such as flavor and drinks, no laboratories have reported that d-ribose is involved in the formaldehyde production. Here, we show that formaldehyde is produced from d-ribose in lysine or glycine solution and Tris-HCl buffer under neutral and alkaline conditions. Intraperitoneal injection of C57BL/6J mice with d-ribose significantly increased the concentration of brain formaldehyde, compared to the injection with d-glucose or saline. These data suggest that formaldehyde levels should be monitored for the people who take d-ribose as a supplement.
基金：
the Beijing Municipal Science and
Technology Project (Z161100000217141; Z161100000216137); the
NSFC (81573763, 31670805); the National Key Research and
Development Program of China (2016YFC1306300); the Chinese
Academy of Sciences (CAS-20140909); and the Queensland-Chinese
Academy of Sciences Biotechnology Fund (GJHZ201302).
语种：
外文
PubmedID：
第一作者：
第一作者机构：[1]State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, University of Chinese Academy of Sciences, Beijing, 100101, China
共同第一作者：
通讯作者：
通讯机构：[1]State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, University of Chinese Academy of Sciences, Beijing, 100101, China[*1]State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing, 100101, China
推荐引用方式(GB/T 7714)：
Wang Yujing,Shi Chenggang,Chen Yao,et al.Formaldehyde produced from d-ribose under neutral and alkaline conditions.[J].Toxicology reports.2019,6:298-304.doi:10.1016/j.toxrep.2019.02.005.
APA：
Wang Yujing,Shi Chenggang,Chen Yao,Yu Lexiang,Li Yiman...&He Rongqiao.(2019).Formaldehyde produced from d-ribose under neutral and alkaline conditions..Toxicology reports,6,
MLA：
Wang Yujing,et al."Formaldehyde produced from d-ribose under neutral and alkaline conditions.".Toxicology reports 6.(2019):298-304
