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Prospective application of stem cells to prevent post-operative skeletal fibrosis.

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机构： [1]Department of Orthopaedics, Orthopaedics Institute, Clinical Medical College of Yangzhou University, Subei People’s Hospital of Jiangsu Province, Yangzhou, Jiangsu 225001, China, [2]Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, West Virginia 26506, [3]Department of Orthopaedics, Chengdu Military General Hospital, Chengdu, Sichuan 610083, China, [4]Exercise Physiology, West Virginia University, Morgantown, West Virginia 26506, [5]WVU Cancer Institute, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, West Virginia 26506

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关键词： epidural fibrosis intraarticular fibrosis peritendinous fibrosis post-operative skeletal fibrosis stem cell

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Post-operative skeletal fibrosis is considered one of the major complications causing dysfunction of the skeletal system and compromising the outcomes of clinical treatment. Limited success has been achieved using current therapies; more effective therapies to reduce post-operative skeletal fibrosis are needed. Stem cells possess the ability to repair and regenerate damaged tissue. Numerous studies show that stem cells serve as a promising therapeutic approach for fibrotic diseases in tissues other than the skeletal system by inhibiting the inflammatory response and secreting favorable cytokines through activating specific signaling pathways, acting as so-called medicinal signaling cells. In this review, current therapies are summarized for post-operative skeletal fibrosis. Given that stem cells are used as a promising therapeutic approach for fibrotic diseases, little effort has been undertaken to use stem cells to prevent post-operative skeletal fibrosis. This review aims at providing useful information for the potential application of stem cells in preventing post-operative skeletal fibrosis in the near future. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:1236-1245, 2019. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

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出版当年[2019]版：

Q2 ORTHOPEDICS

最新[2024]版：

Q2 ORTHOPEDICS

影响因子： 2.3 最新[2024版] 2.9 最新五年平均 2.728 出版当年[2019版] 2.984 出版当年五年平均 3.043 出版前一年[2018版] 3.494 出版后一年[2020版]

第一作者：

第一作者机构： [1]Department of Orthopaedics, Orthopaedics Institute, Clinical Medical College of Yangzhou University, Subei People’s Hospital of Jiangsu Province, Yangzhou, Jiangsu 225001, China, [2]Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, West Virginia 26506,

通讯作者：

通讯机构： [2]Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, West Virginia 26506, [4]Exercise Physiology, West Virginia University, Morgantown, West Virginia 26506, [5]WVU Cancer Institute, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, West Virginia 26506

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