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Targeting cancer stem cell pathways for lung cancer therapy

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资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Liu Mingxin[1] * ; Wu Hong[1] ; Xu Chuan[1,*1] ;
机构： [1]Integrative Cancer Center & Cancer Clinical Research Center, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, PR China
出处：
DOI： 10.1097/CCO.0000000000000912
ISSN：

关键词： lung cancer lung cancer stem cells signaling pathways tumor immune microenvironment

摘要：
The unique properties of cancer stem cells (CSCs) make lung cancer untargetable for quite an extended period. The functional mechanism of this cell type has been illustrated step by step. However, the outcomes of lung cancer patients are still lower than expected clinically. The attempts made by scientists to make challenge history against stemness maintenance of lung cancer cells and their druggable targets are worth elucidating.Many agents, including the Bispecific T-cell engager (BiTE) and AMG 119 targeting DLL3-positive cells, are a tremendous breakthrough in the preclinical and clinical treatment of SCLC. More studies focus on targeting CSCs to overcome TKI resistance in NSCLC. The combo targeting of CSC and the immune microenvironment can favor the treatment of lung cancer patients.The current review elucidates the characteristics and related regulating pathways of lung CSCs from essential to preclinical research. We retrospectively introduce an update on the clinical development of therapeutics targeting CSC-associated developmental signaling pathways and discuss the opportunities to target CSC-immune interactions in lung cancer.Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.

基金：
National Natural Science Foundation of China (81873048 to C.X., 82004006 to H.W., and 2020JDRC012 to B.T.).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 4 区 医学
小类 | 4 区 肿瘤学
最新[2023]版：
大类 | 4 区 医学
小类 | 4 区 肿瘤学
JCR分区：
出版当年[2023]版：
Q2 ONCOLOGY
最新[2023]版：
Q2 ONCOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2022版]

第一作者：
第一作者机构： [1]Integrative Cancer Center & Cancer Clinical Research Center, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, PR China
通讯作者：
通讯机构： [1]Integrative Cancer Center & Cancer Clinical Research Center, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, PR China [*1]Integrative Cancer Center and Cancer Clinical Research Center, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, No. 55, Section 4, South Renmin Road, Chengdu 610041, China
推荐引用方式(GB/T 7714)：
Liu Mingxin,Wu Hong,Xu Chuan.Targeting cancer stem cell pathways for lung cancer therapy[J].CURRENT OPINION IN ONCOLOGY.2023,35(1):78-85.doi:10.1097/CCO.0000000000000912.
APA：
Liu Mingxin,Wu Hong&Xu Chuan.(2023).Targeting cancer stem cell pathways for lung cancer therapy.CURRENT OPINION IN ONCOLOGY,35,(1)
MLA：
Liu Mingxin,et al."Targeting cancer stem cell pathways for lung cancer therapy".CURRENT OPINION IN ONCOLOGY 35..1(2023):78-85

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