机构：[1]State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.[2]Institute of Regulatory Science for Medical Devices, Sichuan University, Chengdu 610064, China.
At present, an oral tumor is usually treated by surgery combined with preoperative or postoperative radiotherapies and chemotherapies. However, traditional chemotherapies frequently result in substantial toxic side effects, including bone marrow suppression, malfunction of the liver and kidneys, and neurotoxicity. As a new local drug delivery system, the smart drug delivery system based on hydrogel can control drug release in time and space, and effectively alleviate or avoid these problems. Environmentally responsive hydrogels for smart drug delivery could be triggered by temperature, photoelectricity, enzyme, and pH. An overview of the most recent research on smart hydrogels and their controlled-release drug delivery systems for the treatment of oral cancer is given in this review. It is anticipated that the local drug release method and environment-responsive benefits of smart hydrogels will offer a novel technique for the low-toxicity and highly effective treatment of oral malignancy.
基金：
National Natural Science Foundation (32171354),
and the Fundamental Research Funds for Central Universities.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类|3 区化学
小类|3 区高分子科学
最新[2023]版：
大类|3 区化学
小类|2 区高分子科学
第一作者：
第一作者机构：[1]State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
通讯作者：
推荐引用方式(GB/T 7714)：
Zhao Yiwen,Ran Bei,Xie Xi,et al.Developments on the Smart Hydrogel-Based Drug Delivery System for Oral Tumor Therapy[J].Gels (Basel, Switzerland).2022,8(11):doi:10.3390/gels8110741.
APA：
Zhao Yiwen,Ran Bei,Xie Xi,Gu Wanrong,Ye Xiuwen&Liao Jinfeng.(2022).Developments on the Smart Hydrogel-Based Drug Delivery System for Oral Tumor Therapy.Gels (Basel, Switzerland),8,(11)
MLA：
Zhao Yiwen,et al."Developments on the Smart Hydrogel-Based Drug Delivery System for Oral Tumor Therapy".Gels (Basel, Switzerland) 8..11(2022)
