机构：[1]Department of Head and Neck Surgery, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610041, China外科中心头颈外科中心四川省人民医院四川省肿瘤医院头颈外科[2]Department of internal medicine, Sichuan Provincial People’s Hospital, Chengdu, 610072, China四川省人民医院[3]College of Basic Medicine, Chengdu Medical College, Chengdu, 610500, China
This study aimed to unravel the molecular mechanism of oral squamous cell carcinoma (OSCC). With microarray dataset GSE30784, differentially expressed genes (DEGs) were identified between OSCC and control samples. The DEGs overlapped with genes obtained from online database MalaCards were determined as OSCCDEG, followed by Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. A total of 5177 up-regulated and 6081 down-regulated DEGs were identified between OSCC and control. Out of the DEGs, 451 genes were overlapped with the 704 genes gained from MalaCards and regarded as "OSCCDEG". Up-regulated OSCCDEG were associated with cell cycle pathway, while down-regulated OSCCDEG were linked to ErbB pathway. ANGPT1, ANGPT2 and 3 hub proteins (EGFR, HSP90AA1, RB1) in the PPI network were associated with the survival rates of several tumors. The largest network module with the hub protein EGFR was associated with positive regulation of cell communication. The second largest module with the hub node FN1 was related to angiogenesis. For the third network module in connection with DNA metabolism, the hub protein was PCNA. ErbB and cell cycle pathways were crucial for OSCC. EGFR, FN1, PCNA, ANGPT1 and ANGPT2 might be potential biomarkers for OSCC. These findings help provide guidelines for treating OSCC.
基金：
This study was supported by Project Grants of Science and Technology Bureau of Chengdu (2012); Project Grants of Youth Science and Technology Innovation Team of Sichuan Province (2014TD0011).
第一作者机构：[1]Department of Head and Neck Surgery, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610041, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
X. LI,R. SUN,X. GENG,et al.A comprehensive analysis of candidate gene signatures in oral squamous cell carcinoma[J].NEOPLASMA.2017,64(2):167-+.doi:10.4149/neo_2017_201.
APA：
X. LI,R. SUN,X. GENG,S. WANG,D. ZEN...&C. LI.(2017).A comprehensive analysis of candidate gene signatures in oral squamous cell carcinoma.NEOPLASMA,64,(2)
MLA：
X. LI,et al."A comprehensive analysis of candidate gene signatures in oral squamous cell carcinoma".NEOPLASMA 64..2(2017):167-+
