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A comprehensive analysis of candidate gene signatures in oral squamous cell carcinoma

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机构： [1]Univ Elect Sci & Technol China, Sch Med, Dept Head & Neck Surg, Sichuan Canc Hosp & Inst,Sichuan Canc Ctr, Chengdu 610041, Peoples R China [2]Sichuan Prov Peoples Hosp, Dept Internal Med, Chengdu 610072, Peoples R China [3]Chengdu Med Coll, Coll Basic Med, Chengdu 610500, Peoples R China

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关键词： oral squamous cell carcinoma network module differentially expressed genes protein-protein interaction gene ontology

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This study aimed to unravel the molecular mechanism of oral squamous cell carcinoma (OSCC). With microarray dataset GSE30784, differentially expressed genes (DEGs) were identified between OSCC and control samples. The DEGs overlapped with genes obtained from online database MalaCards were determined as OSCCDEG, followed by Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. A total of 5177 up-regulated and 6081 down-regulated DEGs were identified between OSCC and control. Out of the DEGs, 451 genes were overlapped with the 704 genes gained from MalaCards and regarded as "OSCCDEG". Up-regulated OSCCDEG were associated with cell cycle pathway, while down-regulated OSCCDEG were linked to ErbB pathway. ANGPT1, ANGPT2 and 3 hub proteins (EGFR, HSP90AA1, RB1) in the PPI network were associated with the survival rates of several tumors. The largest network module with the hub protein EGFR was associated with positive regulation of cell communication. The second largest module with the hub node FN1 was related to angiogenesis. For the third network module in connection with DNA metabolism, the hub protein was PCNA. ErbB and cell cycle pathways were crucial for OSCC. EGFR, FN1, PCNA, ANGPT1 and ANGPT2 might be potential biomarkers for OSCC. These findings help provide guidelines for treating OSCC.

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出版当年[2017]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

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第一作者机构： [1]Univ Elect Sci & Technol China, Sch Med, Dept Head & Neck Surg, Sichuan Canc Hosp & Inst,Sichuan Canc Ctr, Chengdu 610041, Peoples R China

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