机构：[1]Key Laboratory of Molecular Biology in High CancerIncidence Coastal Chaoshan Area of Guangdong HigherEducation Institutes, Shantou University Medical College,Shantou 515041, China[2]Department of Biochemistry and Molecular Biology, ShantouUniversity Medical College, Shantou 515041, China[3]Department of Pathology, Shantou Central Hospital,Affiliated Shantou Hospital of Sun Yat-sen University,Shantou 515041, China[4]Institute of Oncologic Pathology, Shantou UniversityMedical College, Shantou 515041, China[5]Network and Information Center, Shantou UniversityMedical College, Shantou 515041, China[6]Tumor Hospital Affiliated to Xinjiang Medical University,Ürümqi 830054, Xinjiang Uygur Autonomous Region, China[7]Department of Thoracic Surgery, West China Hospitalof Sichuan University, Sichuan 610041, China
Heat-shock proteins (HSPs), one of the evolutionarily conserved protein families, are widely found in various organisms, and play important physiological functions. Nevertheless, HSPs have not been systematically analyzed in esophageal squamous cell carcinoma (ESCC). In this study, we applied the protein-protein interaction (PPI) network methodology to explore the characteristics of HSPs, and integrate their expression in ESCC. First, differentially expressed HSPs in ESCC were identified from our previous RNA-seq data. By constructing a specific PPI network, we found differentially expressed HSPs interacted with hundreds of neighboring proteins. Subcellular localization analyses demonstrated that HSPs and their interacting proteins distributed in multiple layers, from membrane to nucleus. Functional enrichment annotation analyses revealed known and potential functions for HSPs. KEGG pathway analyses identified four significant enrichment pathways. Moreover, three HSPs (DNAJC5B, HSPA1B, and HSPH1) could serve as promising targets for prognostic prediction in ESCC, suggesting these HSPs might play a significant role in the development of ESCC. These multiple bioinformatics analyses have provided a comprehensive view of the roles of heat-shock proteins in esophageal squamous cell carcinoma.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|3 区生物
小类|3 区生化与分子生物学
最新[2023]版：
大类|3 区生物学
小类|3 区生化与分子生物学
第一作者：
第一作者机构：[1]Key Laboratory of Molecular Biology in High CancerIncidence Coastal Chaoshan Area of Guangdong HigherEducation Institutes, Shantou University Medical College,Shantou 515041, China[2]Department of Biochemistry and Molecular Biology, ShantouUniversity Medical College, Shantou 515041, China
通讯作者：
通讯机构：[1]Key Laboratory of Molecular Biology in High CancerIncidence Coastal Chaoshan Area of Guangdong HigherEducation Institutes, Shantou University Medical College,Shantou 515041, China[2]Department of Biochemistry and Molecular Biology, ShantouUniversity Medical College, Shantou 515041, China
推荐引用方式(GB/T 7714)：
Sun Hong,Cai Xinyi,Zhou Haofeng,et al.The protein-protein interaction network and clinical significance of heat-shock proteins in esophageal squamous cell carcinoma.[J].Amino acids.2018,50(6):685-697.doi:10.1007/s00726-018-2569-8.
APA：
Sun Hong,Cai Xinyi,Zhou Haofeng,Li Xiaoqi,Du Zepeng...&Wu Bingli.(2018).The protein-protein interaction network and clinical significance of heat-shock proteins in esophageal squamous cell carcinoma..Amino acids,50,(6)
MLA：
Sun Hong,et al."The protein-protein interaction network and clinical significance of heat-shock proteins in esophageal squamous cell carcinoma.".Amino acids 50..6(2018):685-697
