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Assessment for prognostic value of differentially expressed genes in immune microenvironment of clear cell renal cell carcinoma.

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Pubmed体系：
作者：
Yin Xiaoxue[1,2] * ; Zhang Xingming[3,4] * ; Liu Zhenhua[3,4] * ; Sun Guangxi[3,4] ; Zhu Xudong[3,4] ; Zhang Haoran[3,4] ; Zhu Sha[3,4] ; Zhao Jinge[3,4] ; Chen Junru[3,4] ; Shen Pengfei[3,4] ; Wang Jia[3,4] ; Chen Ni[1,2] ; Zhou Qiao[1,2,*2] ; Zeng Hao[3,4,*1] ;
机构： [1]Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, P. R. China [2]Institute of Pathology, West China Hospital, Sichuan University, Chengdu 610041, P. R. China [3]Department of Urology, West China Hospital, Sichuan University, Chengdu 610041, P. R. China [4]Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, P. R. China
出处：
ISSN：

关键词： Clear cell renal cell carcinoma immune microenvironment differentially expressed genes prognosis

摘要：
Tumor-infiltrating immune cells have been recognized to be associated with prognosis and response to immunotherapy; however, genes related to immune microenvironment of clear cell renal cell carcinoma (ccRCC) remains unclear. To better understand the effects of genes involved in immune and stromal cells on prognosis, we used Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma (TCGA-KIRC), DAVID database and ESTMATE algorithm, and divided the patients into low and high groups according to immune (median: 1038.45) and stromal scores (median: 667.945), respectively. We found the immune scores were significantly correlated with clinicopathological parameters and overall survival (OS). Based on immune scores, 890 DEGs were significantly associated with OS among the 1433 up-regulated genes. Based on top 10 DEGs (IL10RA, FCER1G, SASH3, TIGIT, RHOH, IL12RB1, AIF1, LPXN, LAPTM5 and SP140), cases with number of up-regulated genes ≥ 5 were associated poor OS (P = 0.002). In addition, the mean differences of percentages of CD8 T cells (11.32%), CD4 memory resting T cells (-4.52%) and mast resting cells (-3.55%) between low and high immune scores were the most significant. Thus, combination of these genes might use to predict the efficacy of immunotherapy. Further analyses of these genes were warrant to explore their potential association with the prognosis of ccRCC. AJTR Copyright © 2020.

基金：
Natural Science Foundation of China (NSFC 81974398, 819-02577 and 81672547) and 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University (No.0040205301E21).
语种：
外文
PubmedID：
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出版当年[2020]版：
大类 | 3 区 医学
小类 | 3 区 肿瘤学 3 区 医学：研究与实验
最新[2023]版：
大类 | 4 区 医学
小类 | 4 区 医学：研究与实验 4 区 肿瘤学
第一作者：
第一作者机构： [1]Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, P. R. China [2]Institute of Pathology, West China Hospital, Sichuan University, Chengdu 610041, P. R. China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, P. R. China [2]Institute of Pathology, West China Hospital, Sichuan University, Chengdu 610041, P. R. China [3]Department of Urology, West China Hospital, Sichuan University, Chengdu 610041, P. R. China [4]Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, P. R. China [*1]Department of Urology, West China Hospital, Sichuan University, Chengdu 610041, P. R. China.Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, P. R. China. [*2]Department of Pathology, West China Hospital, Sichuan University, No. 37 Guoxue Xiang, Chengdu 610041, Sichuan,China.Institute of Pathology, West China Hospital, Sichuan University, No. 37 Guoxue Xiang, Chengdu 610041, Sichuan, China.
推荐引用方式(GB/T 7714)：
Yin Xiaoxue,Zhang Xingming,Liu Zhenhua,et al.Assessment for prognostic value of differentially expressed genes in immune microenvironment of clear cell renal cell carcinoma.[J].American journal of translational research.2020,12(9):5416-5432.
APA：
Yin Xiaoxue,Zhang Xingming,Liu Zhenhua,Sun Guangxi,Zhu Xudong...&Zeng Hao.(2020).Assessment for prognostic value of differentially expressed genes in immune microenvironment of clear cell renal cell carcinoma..American journal of translational research,12,(9)
MLA：
Yin Xiaoxue,et al."Assessment for prognostic value of differentially expressed genes in immune microenvironment of clear cell renal cell carcinoma.".American journal of translational research 12..9(2020):5416-5432

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