机构：[1]Department of Pharmacy, Sichuan Cancer Hospital&Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China临床药学部临床药学部四川省人民医院四川省肿瘤医院[2]Department of Pharmacy, Chengdu Medical College, Chengdu, China[3]Department of Clinical Laboratory, Mianyang Central Hospital, Mianyang, China[4]Department of Pharmacy, Key Laboratory of Reproductive Medicine, Sichuan Provincial Hospital for Women and Children, Women and Children's Hospital of Chengdu Medical College, Chengdu Medical College, Chengdu, China[5]Personalized Drug Therapy Key Laboratory of Sichuan Province, Chengdu, Sichuan, China
Combination treatment through simultaneous delivery of anticancer drugs and gene with nano-formulation has been demonstrated to be an elegant and efficient approach for colorectal cancer therapy. Recently, sorafenib being studied in combination therapy in colorectal cancer (CRC) attracted attention of researchers. On the basis of our previous study, pigment epithelium-derived factor (PEDF) loaded nanoparticles showed good effect on CRC in vitro and in vivo. Herein, we designed a combination therapy for sorafenib (Sora), a multi-kinase inhibitor and PEDF, a powerful antiangiogenic gene, in a nano-formulation aimed to increase anti-tumor effect on CRC for the first time. Sora and PEDF were simultaneously encapsulated in PEG-PLGA based nanoparticles by a modified double-emulsion solvent evaporation method. The obtained co-encapsulated nanoparticles (Sora@PEDF-NPs) showed high entrapment efficiency of both Sora and PEDF - and exhibited a uniform spherical morphology. The release profiles of Sora and PEDF were in a sustained manner. The most effective tumor growth inhibition in the C26 cells and C26-bearing mice was observed in the Sora@PEDF-NPs in comparison with none-drug nanoparticles, free Sora, mono-drug nanoparticles (Sora-NPs and PEDF-NPs) and the mixture of Sora-NPs and equivalent PEDF-NPs (Mix-NPs). More importantly, Sora@PEDF-NPs showed lower toxicity than free Sora in mice according to the acute toxicity test. The serologic biochemical analysis and mice body weight during therapeutic period revealed that Sora@PEDF-NPs had no obvious toxicity. All the data demonstrated that the simultaneously loaded nanoparticles with multi-kinase inhibitor and anti-angiogenic gene might be one of the most potential formulations in the treatment of colorectal carcinoma in clinic and worthy of further investigation.
基金：
Cadre Health Care Research Project of Sichuan Province [2019-801]; Sichuan Cancer Hospital Institute [YB2019001]; Health Department of Sichuan Province [100491, 120111, 17ZD038]; Hospital Independently Funded the Project of Sichuan [CYFY16DL-01]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81803931, 81703922]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|2 区医学
小类|2 区医学：研究与实验2 区药学
最新[2023]版：
大类|2 区医学
小类|1 区药学2 区医学：研究与实验
JCR分区：
出版当年[2019]版：
Q1PHARMACOLOGY & PHARMACYQ1MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q1MEDICINE, RESEARCH & EXPERIMENTALQ1PHARMACOLOGY & PHARMACY
第一作者机构：[1]Department of Pharmacy, Sichuan Cancer Hospital&Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Pharmacy, Sichuan Cancer Hospital&Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China[5]Personalized Drug Therapy Key Laboratory of Sichuan Province, Chengdu, Sichuan, China[*1]Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, No. 55, Section 4, Renmin Nan Road, Chengdu, Sichuan 610041, China
推荐引用方式(GB/T 7714)：
Chen Yan,Li NingXi,Xu Bei,et al.Polymer-based nanoparticles for chemo/gene-therapy: Evaluation its therapeutic efficacy and toxicity against colorectal carcinoma[J].BIOMEDICINE & PHARMACOTHERAPY.2019,118:doi:10.1016/j.biopha.2019.109257.
APA：
Chen, Yan,Li, NingXi,Xu, Bei,Wu, Min,Yan, XiaoYan...&Xiao, HongTao.(2019).Polymer-based nanoparticles for chemo/gene-therapy: Evaluation its therapeutic efficacy and toxicity against colorectal carcinoma.BIOMEDICINE & PHARMACOTHERAPY,118,
MLA：
Chen, Yan,et al."Polymer-based nanoparticles for chemo/gene-therapy: Evaluation its therapeutic efficacy and toxicity against colorectal carcinoma".BIOMEDICINE & PHARMACOTHERAPY 118.(2019)
医学