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Synthesis of silver nanoparticles using oxidized amylose and combination with curcumin for enhanced antibacterial activity.

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机构： [a]Department of Pharmaceutics and Bioengineering, School of Chemical Engineering, Sichuan University, Chengdu 610065, PR China [b]Cancer Institute, Affiliated Hospital of Qingdao University, Qingdao 266061, PR China [c]Research Institute of Natural Gas Technology, Petro China Southwest Oil & Gas Field Company, Chengdu 610213, PR China [d]State Key Laboratory of Oral Diseases, Department of Orthodontics and Paediatrics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China

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关键词： Oxidized amylose Silver nanoparticle Curcumin Antibacterial activity Combination therapy Inclusion complex

摘要：

Many kinds of multi-drug-resistant microorganisms have appeared. Moreover, monotherapy is increasingly no longer adequate for many complicated bacterial infections. Therefore, development of efficient combination antibacterial agent is becoming crucial. Herein, we present a hybrid antibacterial agent with enhanced antibacterial activity and high aqueous dissolubility based on silver nanoparticles and curcumin. The silver nanoparticles were firstly synthesized using oxidized amylose as an environmentally friendly reducing agent and stabilizer. Then, curcumin was added into the above mixture to get the hybrid antibacterial agent. The hybrid antibacterial agent presented high dissolubility in aqueous solution and enhanced antibacterial activity. In addition, the hybrid antibacterial agent presented good antioxidant activity and cell compatibility. Overall, the developed hybrid antibacterial agent has a potential to combat multiple bacteria-induced infections of wound surfaces. Copyright © 2019 Elsevier Ltd. All rights reserved.

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出版当年[2020]版：

大类 | 1 区

工程技术

小类 | 1 区应用化学 1 区有机化学 1 区高分子科学

最新[2023]版：

大类 | 1 区

化学

小类 | 1 区应用化学 1 区有机化学 1 区高分子科学

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第一作者机构： [a]Department of Pharmaceutics and Bioengineering, School of Chemical Engineering, Sichuan University, Chengdu 610065, PR China

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