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Self-Assembled Metal-Phenolic Nanoparticles for Enhanced Synergistic Combination Therapy against Colon Cancer.

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机构: [1]Department of Biomass Science and Engineering, Sichuan University, Chengdu, 610065, China. [2]Faculty of Health Sciences, University of Macau, Macau SAR, 999078, China. [3]Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA. [4]Department of Environmental Science and Engineering, College of Environment and Resources, Fuzhou University, Fuzhou, 350108, China. [5]Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, 02115, USA. [6]ARC Centre of Excellence in Convergent Bio-Nano Science and Technology and Department of Chemical Engineering, The University of Melbourne, Parkville, Victoria, 3010, Australia. [7]Laboratory of Ethnopharmacology, Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
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Engineering functional nanomaterials to have both high therapeutic efficacy and minimal side-effects has become a promising strategy for next-generation cancer treatments. Herein, an adenosine triphosphate (ATP) depletion and reactive oxygen species-enhanced combination chemotherapy platform is introduced whereby therapeutic samarium (Sm3+ ) ions and (-)-epicatechin (EC) are integrated via a metal-phenolic network (SmIII -EC). The independent pathway between Sm3+ and EC can achieve a synergistic therapeutic effect through the mitochondrial dysfunction process. SmIII -EC nanoparticles cause a significant reduction of viability of C26 murine colon carcinoma cells while with lower systemic toxic effects on normal cell lines. SmIII -EC nanoparticles are used to directly compare with a clinic anticancer drug 5-fluorouracil. SmIII -EC nanoparticles not only decrease the tumor volume but also do not affect the body weight of mice and normal organs, showing significant advantages over clinic counterpart. These facts suggest that SmIII -EC nanoparticles represent a clinically promising candidate for colon cancer treatment with a targeted therapeutic effect and minimum side toxicity. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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第一作者机构: [1]Department of Biomass Science and Engineering, Sichuan University, Chengdu, 610065, China.
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通讯机构: [1]Department of Biomass Science and Engineering, Sichuan University, Chengdu, 610065, China. [5]Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, 02115, USA.
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