机构：[1]State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China[2]Affiliated Hospital of North Sichuan Medical College, Nanchong, China[3]Department of Head and Neck Surgery, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China外科中心头颈外科中心四川省人民医院四川省肿瘤医院头颈外科[4]State Key Laboratory of Microbial Technology, Shandong University, Qingdao, China
Emerging evidence has shown that dynamic crosstalk among cells in the tumor microenvironment modulates the progression and chemotherapeutic responses of cancer. Extracellular vesicles comprise a crucial form of intracellular communication through horizontal transfer of bioactive molecules, including long non-coding RNA (lncRNA), to neighboring cells. Three main types of extracellular vesicles are exosomes, microvesicles and apoptotic bodies, exhibiting a wide range of sizes and different biogenesis. Over the last decade, dysregulation of extracellular vesicle lncRNA has been revealed to remodel the tumor microenvironment and induce aggressive phenotypes of tumor cells, thereby facilitating tumor growth and development. This review will focus on extracellular vesicle lncRNA-mediated crosstalk between tumor cells and recipient cells, including tumor cells as well as stromal cells in the tumor microenvironment, and overview the mechanisms by which lncRNA are selectively sorted into extracellular vesicles, which may pave the way for their clinical application in cancer diagnosis and treatment.
基金：
Financial support was received through National Key R&D Program
of China (No. 2019YFA09005700) and National Natural Science Foundation of China grants (Nos 81672672, 81972542, 81902779
and 21838002).
第一作者机构：[1]State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China
共同第一作者：
通讯作者：
通讯机构：[1]State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China[4]State Key Laboratory of Microbial Technology, Shandong University, Qingdao, China[*1]State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China College of Stomatology, Sichuan University. No. 14, Sec. 3, Renminnan Road, Chengdu 610041, Sichuan, China.[*2]State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, Shandong, China.
推荐引用方式(GB/T 7714)：
Wei-long Zhang,Yan Liu,Jian Jiang,et al.Extracellular vesicle long non-coding RNA-mediated crosstalk in the tumor microenvironment: Tiny molecules, huge roles[J].CANCER SCIENCE.2020,111(8):2726-2735.doi:10.1111/cas.14494.
APA：
Wei-long Zhang,Yan Liu,Jian Jiang,Ya-Jie Tang,Ya-ling Tang&Xin-hua Liang.(2020).Extracellular vesicle long non-coding RNA-mediated crosstalk in the tumor microenvironment: Tiny molecules, huge roles.CANCER SCIENCE,111,(8)
MLA：
Wei-long Zhang,et al."Extracellular vesicle long non-coding RNA-mediated crosstalk in the tumor microenvironment: Tiny molecules, huge roles".CANCER SCIENCE 111..8(2020):2726-2735
医学