机构：[1]Shanghai Children’s Hospital, Shanghai Institute of Medical Genetics, Shanghai Jiao Tong University School of Medicine, 24/1400 West Beijing Rd., Shanghai 200040, China[2]Key Laboratory of Embryo Molecular Biology, Ministry of Health of China and Shanghai Key Laboratory of Embryo and Reproduction Engineering, Shanghai 200040, China[3]State Key Laboratory of Biocherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China四川大学华西医院
Colorectal cancer (CRC), one of the most malignant cancers, is currently the fourth leading cause of cancer deaths worldwide. Recent studies indicated that long non-coding RNAs (lncRNAs) could be robust molecular prognostic biomarkers that can refine the conventional tumor-node-metastasis staging system to predict the outcomes of CRC patients. In this study, the lncRNA expression profiles were analyzed in five datasets (GSE24549, GSE24550, GSE35834, GSE50421, and GSE31737) by probe set reannotation and an lncRNA classification pipeline. Twenty-five lncRNAs were differentially expressed between CRC tissue and tumor-adjacent normal tissue samples. In these 25 lncRNAs, patients with higher expression of LINC01296, LINC00152, and FIRRE showed significantly better overall survival than those with lower expression (P < 0.05), suggesting that these lncRNAs might be associated with prognosis. Multivariate analysis indicated that LINC01296 overexpression was an independent predictor for patients' prognosis in the test datasets (GSE24549, GSE24550) (P = 0.001) and an independent validation series (GSE39582) (P = 0.027). Our results suggest that LINC01296 could be a novel prognosis biomarker for the diagnosis of CRC.
基金：
This work was supported by grants from the National Basic Research Project of China (2010CB529502 and
2007CB511904), National Natural Science Foundation of China
(81471485), and the Key Program for the Fundamental Research of the
Science and Technology Commission of Shanghai (11JC1411000).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类|3 区医学
小类|3 区肿瘤学
最新[2023]版：
无
第一作者：
第一作者机构：[1]Shanghai Children’s Hospital, Shanghai Institute of Medical Genetics, Shanghai Jiao Tong University School of Medicine, 24/1400 West Beijing Rd., Shanghai 200040, China
通讯作者：
通讯机构：[1]Shanghai Children’s Hospital, Shanghai Institute of Medical Genetics, Shanghai Jiao Tong University School of Medicine, 24/1400 West Beijing Rd., Shanghai 200040, China[2]Key Laboratory of Embryo Molecular Biology, Ministry of Health of China and Shanghai Key Laboratory of Embryo and Reproduction Engineering, Shanghai 200040, China[3]State Key Laboratory of Biocherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
推荐引用方式(GB/T 7714)：
Qiu Jia-Jun,Yan Jing-Bin.Long non-coding RNA LINC01296 is a potential prognostic biomarker in patients with colorectal cancer.[J].Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.2015,36(9):7175-83.doi:10.1007/s13277-015-3448-5.
APA：
Qiu Jia-Jun&Yan Jing-Bin.(2015).Long non-coding RNA LINC01296 is a potential prognostic biomarker in patients with colorectal cancer..Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine,36,(9)
MLA：
Qiu Jia-Jun,et al."Long non-coding RNA LINC01296 is a potential prognostic biomarker in patients with colorectal cancer.".Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 36..9(2015):7175-83
