机构：[1]Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Department of Pediatric Hematology/Oncology, West China Second Hospital of Sichuan University, Chengdu, China[2]Department of Hematology/Oncology, Shanghai Children's Medical Center, Shanghai Jiaotong University of School of Medicine, Shanghai, China[3]Department of Hematology/Oncology, Children's Hospital of Chongqing Medical University, Chongqing, China[4]State Key Laboratory of Experimental Hematology and Division of Pediatric Blood Diseases Center, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China[5]Department of Pediatrics, Anhui Medical University Second Affiliated Hospital, Hefei, China[6]Department of Hematology/Oncology, Children's Hospital of Soochow University, Suzhou, China[7]Department of Pediatrics, Nanfang Hospital, Southern Medical University, Guangzhou, China[8]Department of Paediatrics, Hong Kong Children's Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China[9]Department of Pediatrics, Affiliated Hospital of Qingdao University, Qingdao, China[10]Department of Hematology/Oncology, Guangzhou Women and Children Health Care Center, Guangzhou, China[11]Department of Pediatrics, Qilu Hospital of Shandong University, Jinan, China[12]Department of Hematology/Oncology, Kunming Children's Hospital, Kunming, China[13]Department of Pediatric Hematology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China华中科技大学同济医学院附属同济医院[14]Department of Pediatrics, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China华中科技大学同济医学院附属协和医院[15]Department of Hematology/Oncology, Xi'an Northwest Women and Children Hospital, Xian, China[16]Department of Hematology/Oncology, Nanjing Children's Hospital Affiliated to Nanjing Medical University, Nanjing, China[17]Department of Hematology Oncology, Children's hospital of Fudan University, Shanghai, China[18]Department of Hematology Oncology, Children's Hospital Affiliated to Shanghai Jiaotong University, Shanghai, China
Background Septicemia is an important cause of treatment-related mortality and treatment failure in pediatric acute lymphoblastic leukemia (ALL) in developing countries. A multicenter CCCG-ALL-2015 study was conducted in China and factors associated with septicemia and mortality were studied. Methods Patients participated in CCCG-ALL-2015 study from January 2015 to December 2017 were included. Patients with documented septicemia were identified from the Data Center and additional data were collected. Results A total of 4080 patients were recruited in the study and 527 patients with septicemia were identified (12.9%, 95% CI 11.9%-13.9%). The intermediate risk (IR)/high risk (HR) group had significantly higher incidence of septicemia as compared with low risk (LR) group, 17.1% vs 9.1% (OR 2.07, 95% CI 1.71-2.49, P < .001). Induction phase was the period with majority of septicemia episodes happened, 66.8% in LR and 56.1% in IR/HR groups. Gram-positive bacteria accounted for 54.1%, gram-negative bacteria 44.5%, and fungus 1.4% of positive cultures. Multidrug-resistant organisms were detected in 20.5% of all organisms. The mortality rate after septicemia was 3.4% (95% CI 1.9%-4.9%). Multiple logistic regression identified female gender, comorbid complications, and fungal infection as risk factors associated with mortality. Gram-negative septicemia was associated with higher mortality, 4.9% vs 1.4% (OR 0.28, 95% CI 0.09-0.88, P = .02). There was marked variation in the incidence of septicemia among the 18 centers, from 4.8% to 29.1%. Conclusion Overall the incidence and pattern of septicemia in this multicenter study in China was similar to the reports of western countries. The septicemia-related mortality rate was low. There was marked variation in the incidence of septicemia among the centers.
第一作者机构：[1]Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Department of Pediatric Hematology/Oncology, West China Second Hospital of Sichuan University, Chengdu, China
共同第一作者：
通讯作者：
通讯机构：[8]Department of Paediatrics, Hong Kong Children's Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China[*1]Department of Paediatrics, Hong Kong Children's Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China
推荐引用方式(GB/T 7714)：
Yiping Zhu,Rong Yang,Jiaoyang Cai,et al.Septicemia after chemotherapy for childhood acute lymphoblastic leukemia in China: A multicenter study CCCG-ALL-2015[J].CANCER MEDICINE.2020,9(6):2113-2121.doi:10.1002/cam4.2889.
APA：
Yiping Zhu,Rong Yang,Jiaoyang Cai,Jie Yu,Yanjing Tang...&Chi-kong Li.(2020).Septicemia after chemotherapy for childhood acute lymphoblastic leukemia in China: A multicenter study CCCG-ALL-2015.CANCER MEDICINE,9,(6)
MLA：
Yiping Zhu,et al."Septicemia after chemotherapy for childhood acute lymphoblastic leukemia in China: A multicenter study CCCG-ALL-2015".CANCER MEDICINE 9..6(2020):2113-2121
