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Reduced Dose Intensity of Daunorubicin During Remission Induction for Low-Risk Patients With Acute Lymphoblastic Leukemia: A Retrospective Cohort Study of the Chinese Children's Cancer Group.

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机构: [1]Department of Pediatrics, Qilu Hospital of Shandong University, Jinan, China, [2]National Children’s Medical Center, Department of Hematology/Oncology, Key Laboratory of Pediatric Hematology and Oncology of China Ministry of Health, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China, [3]State Key Laboratory of Experimental Hematology and Division of Pediatric Blood Diseases Center, Institute of Hematology and Blood Diseases Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Tianjin, China, [4]Department of Hematology/Oncology, Children’s Hospital of Soochow University, Suzhou, China, [5]Department of Pediatrics, Key Laboratory of Birth Defects and Related Disease of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China, [6]Department of Hematology/Oncology, Guangzhou Women and Children’s Medical Center, Guangzhou, China, [7]Department of Hematology/Oncology, Children’s Hospital of Fudan University, Shanghai, China, [8]Department of Hematology/Oncology, Kunming Children’s Hospital, Kunming, China, [9]Department of Hematology/ Oncology, Children’s Hospital of Nanjing Medical University, Nanjing, China, [10]Department of Pediatrics, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, [11]Department of Pediatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, [12]Department of Hematology/Oncology, Shanghai Children’s Hospital, Shanghai Jiao Tong University, Shanghai, China, [13]Department of Pediatrics, Anhui Medical University Second Affiliated Hospital, Hefei, China, [14]Department of Pediatrics, Affiliated Hospital of Qingdao University, Qingdao, China, [15]Department of Pediatrics, Hong Kong Children’s Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China, [16]Department of Pediatrics, Xiangya Hospital Central South University, Changsha, China, [17]Department of Hematology/Oncology, Xi’an Northwest Women and Children Hospital, Xi’an, China, [18]Department of Pediatrics, Nanfang Hospital, Southern Medical University, Guangzhou, China, [19]Department of Hematology/ Oncology, Jiangxi Provincial Children’s Hospital, Nanchang, China, [20]Department of Hematology/Oncology, Chongqing Medical University Affiliated Children’s Hospital, Chongqing, China
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关键词: acute lymphoblastic leukemia children remission-induction multicenter study daunorubicin

摘要:
It is urgently necessary to reduce the adverse effects of chemotherapy while maintaining their cure high rates for children with acute lymphoblastic leukemia (ALL). The present study aimed to determine whether the dose intensity of daunorubicin during the remission-induction phase could be reduced for low-risk patients with ALL. A total of 2396 eligible patients, who participated in CCCG-ALL-2015 study and were provisionally assigned to the low-risk group, were included and divided into single-dose group and double-dose group according to the dosage of daunorubicin during the remission-induction phase. For patients with ETV6-RUNX1 positive ALL or hyperdiploidy ALL, there were no significant differences in outcomes between the two groups. For other patients, the 5-year event-free survival rate was significantly better and the 5-year cumulative risk of any relapse was significantly lower in the double-dose group compared with the single-dose group. Both the 5-year overall survival rate and the risk of early deaths were not significantly different between the two groups. Our results suggested that only B-lineage ALL patients with ETV6-RUNX1 positivity or hyperdiploidy who achieved an early negative minimal residual disease status were suitable candidates for dosage reduction of daunorubicin during the remission-induction phase.http://www.chictr.org.cn/showproj.aspx?proj=10115, identifier ChiCTR-IPR-14005706.Copyright © 2022 Zhuang, Wu, Zhu, Cai, Hu, Gao, Jiang, Zhai, Tian, Fang, Jin, Hu, Jiang, Wang, Sun, Leung, Yang, Pan, Wu, Liang, Shen, Yu and Ju.

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大类 | 3 区 医学
小类 | 3 区 肿瘤学
最新[2023]版:
大类 | 3 区 医学
小类 | 3 区 肿瘤学
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Q2 ONCOLOGY
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Q2 ONCOLOGY

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第一作者机构: [1]Department of Pediatrics, Qilu Hospital of Shandong University, Jinan, China,
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