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Outcome of children with newly diagnosed acute lymphoblastic leukemia treated with CCLG-ALL 2008: The first nation-wide prospective multicenter study in China

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机构： [1]1Beijing Key Laboratory of Pediatric Hematology Oncology,National Key Discipline of Pediatrics (Capital Medical University),Key Laboratory of Major Diseases in Children, Ministry of Education,Hematology Oncology Center,Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China [2]Hematology and Oncology Laboratory, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China [3]Department of Hematology-Oncology, Children’s Hospital of Soochow University, Soochow, China [4]Department of Hematology Oncology, Children’s Hospital of Chongqing Medical University,Ministry of Education Key Laboratory of Child Development and Disorder, China International Science and Technology Cooperation base of Child development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China [5]Department of Pediatrics, West China Second University Hospital, Sichuan University,Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China [6]Department of Pediatrics, Institute of Hematology and Hospital of Blood Disease, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin, China [7]Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China [8]Department of Hematology and Oncology, Capital Institute of Pediatrics, Beijing, China [9]Department of Pediatrics, Peking University People’s Hospital, Beijing, China [10]Department of Hematology, Children’s Hospital, Shanghai Medical College, Fudan University, Shanghai, China [11]Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China [12]Department of Pediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong,The Hong Kong Pediatric Hematology and Oncology Study Group, Hong Kong, China

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Acute lymphoblastic leukemia (ALL) is the most common malignancy among children. The trial Chinese Children Leukemia Group (CCLG)-ALL 2008 was a prospective clinical trial designed to improve treatment outcome of childhood ALL through the first nation-wide collaborative study in China. Totally 2231 patients were recruited from ten tertiary hospitals in eight cities. The patients were stratified according to clinical-biological characteristics and early treatment response. Standard risk (SR) and intermediate risk (IR) groups were treated with a modified BFM based protocol, and there was 25%-50% dose reduction during intensification phases in the SR group. Patients in high risk (HR) group received a more intensive maintenance treatment. Minimal residual disease (MRD) monitoring with treatment adjustment was performed in two hospitals (the MRD group). Complete remission (CR) was achieved in 2100 patients (94.1%). At five years, the estimate for overall survival (OS) and event-free survival (EFS) of the whole group was 85.3% and 79.9%, respectively. The cumulative incidence of relapse (CIR) was 15.3% at five years. The OS, EFS and CIR for the SR group were 91.5%, 87.9%, and 9.7%, respectively. The outcome of the MRD group is better than the non-MRD group (5y-EFS: 82.4% vs 78.3%, P=.038; 5y-CIR: 10.7% vs 18.0%, P<.001). Our results demonstrated that the large-scale multicenter trial for pediatric ALL was feasible in China. Dose reduction in the SR group could achieve high EFS. MRD-based risk stratification might improve the treatment outcome for childhood ALL.

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出版当年[2018]版：

大类 | 2 区医学

小类 | 2 区血液学

最新[2023]版：

大类 | 1 区

医学

小类 | 2 区血液学

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出版当年[2018]版：

Q1 HEMATOLOGY

最新[2023]版：

Q1 HEMATOLOGY

影响因子： 10.1 最新[2023版] 10.1 最新五年平均 6.137 出版当年[2018版] 5.328 出版当年五年平均 5.303 出版前一年[2017版] 6.973 出版后一年[2019版]

第一作者：

第一作者机构： [1]1Beijing Key Laboratory of Pediatric Hematology Oncology,National Key Discipline of Pediatrics (Capital Medical University),Key Laboratory of Major Diseases in Children, Ministry of Education,Hematology Oncology Center,Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China [2]Hematology and Oncology Laboratory, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China

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通讯作者：

通讯机构： [1]1Beijing Key Laboratory of Pediatric Hematology Oncology,National Key Discipline of Pediatrics (Capital Medical University),Key Laboratory of Major Diseases in Children, Ministry of Education,Hematology Oncology Center,Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China [12]Department of Pediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong,The Hong Kong Pediatric Hematology and Oncology Study Group, Hong Kong, China [*1]Hematology Oncology Center, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China. [*2]Department of Pediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Ngan Shing Street, Shatin, Hong Kong. [*3]Hematology Oncology Center, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China.

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