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A prospective multicenter study on varicella-zoster virus infection in children with acute lymphoblastic leukemia

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机构： [1]Department of Hematology, Jiangsu Children Hematology and Oncology Center Children's Hospital of Soochow University, Suzhou, China. [2]Department of Hematology/Oncology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, National Health Committee Key Laboratory of Pediatric Hematology and Oncology, Shanghai, China. [3]Department of Pediatrics, West China Second University Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Disease of Women and Children, Ministry of Education, Chengdu, China. [4]Department of Hematology/Oncology, Chongqing Medical University Affiliated Children's Hospital, Chongqing, China. [5]Department of Pediatrics, Hong Kong Children's Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China. [6]Department of Hematology/Oncology, Guangzhou Women and Children's Medical Center, Guangzhou, China. [7]Department of Pediatrics, Qilu Hospital of Shandong University, Jinan, China. [8]Department of Pediatrics, Anhui Medical University Second Affiliated Hospital, Anhui, China. [9]Department of Hematology/Oncology, Children's Hospital of Fudan University, Shanghai, China. [10]Department of Pediatrics, State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China. [11]Department of Pediatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [12]Department of Pediatrics, Xiangya Hospital Central South University, Changsha, China. [13]Department of Hematology/Oncology, Children's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China. [14]Department of Hematology/Oncology, Jiangxi Provincial Children's Hospital, Nanchang, China. [15]Department of Hematology/Oncology, KunMing Children's Hospital, Kunming, China. [16]Department of Hematology/Oncology, Children's Hospital of Nanjing Medical University, Nanjing, China. [17]Department of Hematology/Oncology, Xi'an Northwest Women's and Children's Hospital, Xi'an, China. [18]Department of Pediatrics, Nanfang Hospital, Southern Medical University, Guangzhou, China. [19]Department of Pediatrics, Xiehe Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [20]Department of Pediatrics, The Affiliated Hospital of Qingdao Medical University, Qingdao, China.

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关键词： childhood acute lymphoblastic leukemia varicella-zoster infection E2A/PBX1 fusion gene risk factor

摘要：

The study evaluated prognostic factors associated with varicella-zoster virus (VZV) infection and mortality in children with acute lymphoblastic leukemia (ALL) using data from the multicenter Chinese Children's Cancer Group ALL-2015 trial.In total, 7,640 patients were recruited, and 138 cases of VZV infection were identified. The incidence of VZV infection was higher in patients aged ≥ 10 years (22.5%) and in patients with the E2A/PBX1 fusion gene (11.6%) compared to those aged < 10 years (13.25%, P = 0.003) or with other fusion genes (4.9%, P = 0.001). Of the 10 deaths in children with ALL and VZV infection, 4 resulted from VZV complications. The differences between groups in the 5-year overall survival, event-free survival, cumulative recurrence, and death in remission were not statistically significant. The proportion of complex infection was higher in children with a history of exposure to someone with VZV infection (17.9% vs. 3.6%, P = 0.022).VZV exposure was associated with an increased incidence of complex VZV infection and contributed to VZV-associated death in children with ALL.Copyright © 2022 Xiao, Cai, Gao, Gao, Guan, Leung, He, Zhuang, Chu, Zhai, Qi, Liu, Yang, Zhu, Li, Tian, Xue, Hao, Wu, Zhou, Wang, Tang, Shen and Hu.

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出版当年[2022]版：

大类 | 2 区医学

小类 | 2 区微生物学 2 区免疫学

最新[2023]版：

大类 | 2 区医学

小类 | 2 区微生物学 3 区免疫学

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出版当年[2022]版：

Q1 MICROBIOLOGY Q2 IMMUNOLOGY

最新[2023]版：

Q1 MICROBIOLOGY Q2 IMMUNOLOGY

影响因子： 4.6 最新[2023版] 5.1 最新五年平均 5.7 出版当年[2022版] 5.9 出版当年五年平均 6.073 出版前一年[2021版] 4.6 出版后一年[2023版]

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第一作者机构： [1]Department of Hematology, Jiangsu Children Hematology and Oncology Center Children's Hospital of Soochow University, Suzhou, China.

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A prospective multicenter study on varicella-zoster virus infection in children with acute lymphoblastic leukemia

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