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Recent advances in intensity modulated radiotherapy and proton therapy for esophageal cancer

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机构: [1]Sun Yat Sen Univ, State Key Lab Oncol South China, Collaborat Innovat Ctr Canc Med, Dept Radiat Oncol,Canc Ctr, Guangzhou, Guangdong, Peoples R China; [2]Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA; [3]Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Unit 97, 1515 Holcombe Blvd, Houston, TX 77030 USA
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关键词: Esophageal cancer intensity-modulated radiation therapy volumetric modulated arc therapy proton beam therapy dosimetry survival toxicity

摘要:
Introduction: Radiotherapy is an important component of the standard of care for esophageal cancer. In the past decades, significant improvements in the planning and delivery of radiation techniques have led to better dose conformity to the target volume and improved normal tissue sparing.Areas covered: This review focuses on the advances in radiotherapy techniques and summarizes the availably dosimetric and clinical outcomes of intensity-modulated radiation therapy (IMRT), volumetric modulated arc therapy, proton therapy, and four-dimensional radiotherapy for esophageal cancer, and discusses the challenges and future development of proton therapy.Expert commentary: Although three-dimensional conformal radiotherapy is the standard radiotherapy technique in esophageal cancer, the retrospectively comparative studies strongly suggest that the dosimetric advantage of IMRT over three-dimensional conformal radiotherapy can translate into improved clinical outcomes, despite the lack of prospective randomized evidence. As a novel form of conventional IMRT technique, volumetric modulated arc therapy can produce equivalent or superior dosimetric quality with significantly higher treatment efficiency in esophageal cancer. Compared with photon therapy, proton therapy has the potential to achieve further clinical improvement due to their physical properties; however, prospective clinical data, long-term results, and cost-effectiveness are needed.

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出版当年[2017]版
大类 | 4 区 医学
小类 | 4 区 肿瘤学
最新[2023]版
大类 | 3 区 医学
小类 | 4 区 肿瘤学
第一作者:
第一作者机构: [1]Sun Yat Sen Univ, State Key Lab Oncol South China, Collaborat Innovat Ctr Canc Med, Dept Radiat Oncol,Canc Ctr, Guangzhou, Guangdong, Peoples R China;
通讯作者:
通讯机构: [2]Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA; [3]Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Unit 97, 1515 Holcombe Blvd, Houston, TX 77030 USA
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