高级检索
当前位置: 首页 > 详情页

Dosimetric study for cervix carcinoma treatment using intensity modulated radiation therapy (IMRT) compensation based on 3D intracavitary brachytherapy technique

| 导出 | |

文献详情

资源类型:
WOS体系:
Pubmed体系:

收录情况: ◇ SCIE

机构: [1]Department of Radiotherapy, Sichuan Cancer Hospital & Institute, Chengdu [2]Bio-information College, Chongqing University of Postsand Telecommunications, Chongqing [3]Chongqing Key Laboratory of Photoelectronic Information Sensing and Transmiiting Technology,Chongqing [4]Chongqing High School Innovation Team of Architecture and Core Technologies of Smart Medical System, Chongqing [5]Faculty of Health Sciences, University of Macau, Taipa, Macau, China
出处:
ISSN:

关键词: brachytherapy cervical cancer cervix carcinoma dosimetry IMRT

摘要:
Purpose: Intensity modulated radiation therapy (IMRT) compensation based on 3D high-dose-rate (HDR) intracavitary brachytherapy (ICBT) boost technique (ICBT + IMRT) has been used in our hospital for advanced cervix carcinoma patients. The purpose of this study was to compare the dosimetric results of the four different boost techniques (the conventional 2D HDR intracavitary brachytherapy [CICBT], 3D optimized HDR intracavitary brachytherapy [OICBT], and IMRT-alone with the applicator in situ). Material and methods: For 30 patients with locally advanced cervical carcinoma, after the completion of external beam radiotherapy (EBRT) for whole pelvic irradiation 45 Gy/25 fractions, five fractions of ICBT + IMRT boost with 6 Gy/fractions for high risk clinical target volume (HRCTV), and 5 Gy/fractions for intermediate risk clinical target volume (IRCTV) were applied. Computed tomography (CT) and magnetic resonance imaging (MRI) scans were acquired using an in situ CT/MRI-compatible applicator. The gross tumor volume (GTV), the high/intermediate-risk clinical target volume (HRCTV/IRCTV), bladder, rectum, and sigmoid were contoured by CT scans. Results: For ICBT + IMRT plan, values of D-90, D-100 of HRCTV, D-90, D-100, and V-100 of IRCTV significantly increased (p < 0.05) in comparison to OICBT and CICBT. The D2cc values for bladder, rectum, and sigmoid were significantly lower than that of CICBT and IMRT alone. In all patients, the mean rectum V-60 Gy values generated from ICBT + IMRT and OICBT techniques were very similar but for bladder and sigmoid, the V-60 Gy values generated from ICBT + IMRT were higher than that of OICBT. For the ICBT + IMRT plan, the standard deviations (SD) of D-90 and D2cc were found to be lower than other three treatment plans. Conclusions: The ICBT + IMRT technique not only provides good target coverage but also maintains low doses (D2cc) to the OAR. ICBT + IMRT is an optional technique to boost parametrial region or tumor of large size and irregular shape when intracavitary/interstitial brachytherapy cannot be used.

基金:

基金编号: FDCT

语种:
被引次数:
WOS:
PubmedID:
中科院(CAS)分区:
出版当年[2016]版:
大类 | 4 区 医学
小类 | 4 区 肿瘤学 4 区 核医学
最新[2023]版:
大类 | 4 区 医学
小类 | 4 区 肿瘤学 4 区 核医学
JCR分区:
出版当年[2016]版:
Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Q4 ONCOLOGY
最新[2023]版:
Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Q4 ONCOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2016版] 出版当年五年平均 出版前一年[2015版] 出版后一年[2017版]

第一作者:
第一作者机构: [1]Department of Radiotherapy, Sichuan Cancer Hospital & Institute, Chengdu
共同第一作者:
通讯作者:
通讯机构: [5]Faculty of Health Sciences, University of Macau, Taipa, Macau, China [*1]Faculty of Health Sciences, University of Macau, Taipa, Macau, China,
推荐引用方式(GB/T 7714):
APA:
MLA:

资源点击量:43377 今日访问量:0 总访问量:3120 更新日期:2024-09-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 四川省肿瘤医院 技术支持:重庆聚合科技有限公司 地址:成都市人民南路四段55号