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Exploring the pharmacokinetics, drug-likeness, and toxicological features of anticancer flavonoids: a Boulevard to explore their clinical translational potential

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文献详情

资源类型：
Pubmed体系：
作者：
Dubey Ankit Kumar[1,2] * ; Chandragiri Siva Sai[3] * ; Geevarghese Abin V[4] * ; Kapoor Bhupinder[5] ; Gulati Monica[5,6] ; Rani Pooja[5] ; Singh Gursharan[7] ; Chavda Vivek P[8] ; Gundamaraju Rohit[9,10,11] ; Bansal Himangini[12] ; Gautam Rupesh K[1,13,14] ; Goyal Rajat[15] ; Okoh Michael P[1,16] ; Shen Bairong[1] ; Singla Rajeev K[1,5] ;
机构： [1]Department of Pharmacy and Institutes for Systems Genetics, Center for High Altitude Medicine, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China. [2]iGlobal Research and Publishing Foundation, New Delhi, India. [3]Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States. [4]Department of Pharmacology, Faculty of Pharmacy, Karpagam Academy of Higher Education, Coimbatore, Tamil Nadu, India. [5]School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India. [6]Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Sydney, NSW, Australia. [7]Department of Medical Laboratory Sciences, Lovely Professional University, Phagwara, India. [8]Department of Pharmaceutics and Pharmaceutical Technology, L M College of Pharmacy, Ahmedabad, Gujarat, India. [9]ER stress and mucosal immunology lab, School of Health Sciences, University of Tasmania, Launceston, TAS, Australia. [10]School of Medicine, University of California, San Francisco, San Francisco, CA, United States. [11]Department of Pharmaceutical Engineering, B V Raju Institute of Technology, Medak, Telangana, India. [12]Delhi Institute of Pharmaceutical Sciences and Research, New Delhi, India. [13]IES Institute of Pharmacy, IES University, Bhopal, Madhya Pradesh, India. [14]Amity Institute of Pharmacy, Amity University Uttar Pradesh, Noida, India. [15]MM College of Pharmacy, Maharishi Markandeshwar (Deemed to be) University, Mullana-Ambala, Haryana, India. [16]Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Health Sciences, University of Abuja, Abuja, Nigeria.
出处：
DOI： 10.3389/fphar.2025.1648395
ISSN：

关键词： flavonoids anticancer agents pharmacokinetics admet drug toxicity

摘要：
Flavonoids that are widely distributed across various plant species exhibit significant anticancer activity in various preclinical and clinical studies, thus offering promising therapeutic prospects. However, a thorough understanding of their pharmacokinetic properties, drug-likeness characteristics, and safety profile is essential for the translational applicability of these molecules into clinical settings.A systematic search was carried out using various electronic databases such as PubMed Central, ScienceDirect, Clinical Registry, and Google Scholar, using different keywords like "flavonoids", "cancer", "pharmacokinetics", "toxicity", "tumor", and their combinations. Non-English literature was excluded due to language barriers, limited accessibility, non-indexing, and the risk of misinterpreting methods or results, which could compromise the accuracy and reliability of the review.This review provides an in-depth overview of various mechanistic pathways, such as oxidative stress-mediated and immunomodulatory pathways, that are considered to be responsible for the anti-cancer potential of flavonoids. In addition, the pharmacokinetic properties and toxicity profile of flavonoids have been discussed, which are the crucial factors in their clinical translation. Lastly, the review briefly explores various strategies that can be adopted to improve the effectiveness of flavonoids in the treatment of cancer.This investigation enhances our understanding of the translational potential of flavonoid-based therapies by highlighting these essential elements, bringing us one step closer to the development of effective and safe cancer treatments.Copyright © 2025 Dubey, Chandragiri, Geevarghese, Kapoor, Gulati, Rani, Singh, Chavda, Gundamaraju, Bansal, Gautam, Goyal, Okoh, Shen and Singla.

基金：
This work was supported by the Sichuan Science and Technology Program (Grant Nos. 2025YFHZ0213 and 2024YFHZ0205) and the National Natural Science Foundation of China (Grant No. 32270690).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类 | 3 区 医学
小类 | 3 区 药学
最新[2025]版：
大类 | 3 区 医学
小类 | 3 区 药学
第一作者：
第一作者机构： [1]Department of Pharmacy and Institutes for Systems Genetics, Center for High Altitude Medicine, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China. [2]iGlobal Research and Publishing Foundation, New Delhi, India.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Pharmacy and Institutes for Systems Genetics, Center for High Altitude Medicine, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China. [5]School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
推荐引用方式(GB/T 7714)：
Dubey Ankit Kumar,Chandragiri Siva Sai,Geevarghese Abin V,et al.Exploring the pharmacokinetics, drug-likeness, and toxicological features of anticancer flavonoids: a Boulevard to explore their clinical translational potential[J].Frontiers In Pharmacology.2025,16:1648395.doi:10.3389/fphar.2025.1648395.
APA：
Dubey Ankit Kumar,Chandragiri Siva Sai,Geevarghese Abin V,Kapoor Bhupinder,Gulati Monica...&Singla Rajeev K.(2025).Exploring the pharmacokinetics, drug-likeness, and toxicological features of anticancer flavonoids: a Boulevard to explore their clinical translational potential.Frontiers In Pharmacology,16,
MLA：
Dubey Ankit Kumar,et al."Exploring the pharmacokinetics, drug-likeness, and toxicological features of anticancer flavonoids: a Boulevard to explore their clinical translational potential".Frontiers In Pharmacology 16.(2025):1648395

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