Mitochondria play a key role in ATP generation, redox homeostasis and regulation of apoptosis. Due to the essential role of mitochondria in metabolism and cell survival, targeting mitochondria in cancer cells is considered as an attractive therapeutic strategy. However, metabolic flexibility in cancer cells may enable the upregulation of compensatory pathways, such as glycolysis to support cancer cell survival when mitochondrial metabolism is inhibited. Thus, compounds capable of both targeting mitochondria and inhibiting glycolysis may be particularly useful to overcome such drug-resistant mechanism. This review provides an update on recent development in the field of targeting mitochondria and novel compounds that impact mitochondria, glycolysis or both. Key challenges in this research area and potential solutions are also discussed.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81430060, 81672952]; Guangzhou Technology Program [201504010038, 201508020250]; Guangzhou Innovative Research Program [LCY201317]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|3 区医学
小类|2 区药物化学
最新[2023]版：
大类|4 区医学
小类|4 区药物化学
第一作者：
第一作者机构：[1]Sun Yat Sen Univ, Canc Ctr, State Key Lab Oncol South China, Collaborat Innovat Ctr Canc Med, Guangzhou 510060, Guangdong, Peoples R China;
通讯作者：
通讯机构：[1]Sun Yat Sen Univ, Canc Ctr, State Key Lab Oncol South China, Collaborat Innovat Ctr Canc Med, Guangzhou 510060, Guangdong, Peoples R China;[2]Univ Texas MD Anderson Canc Ctr, Dept Translat Mol Pathol, Houston, TX 77030 USA
推荐引用方式(GB/T 7714)：
Cui Qingbin,Wen Shijun,Huang Peng.Targeting cancer cell mitochondria as a therapeutic approach: recent updates[J].FUTURE MEDICINAL CHEMISTRY.2017,9(9):929-+.doi:10.4155/fmc-2017-0011.
APA：
Cui, Qingbin,Wen, Shijun&Huang, Peng.(2017).Targeting cancer cell mitochondria as a therapeutic approach: recent updates.FUTURE MEDICINAL CHEMISTRY,9,(9)
MLA：
Cui, Qingbin,et al."Targeting cancer cell mitochondria as a therapeutic approach: recent updates".FUTURE MEDICINAL CHEMISTRY 9..9(2017):929-+
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