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(Spiro) phenanthrenes and bibenzyls in Dendrobium chrysotoxum Lindl and their cytotoxic as well as anti-pulmonary fibrosis activities

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机构： [1]Key Laboratory of Environmental and Applied Microbiology, Environmental Microbiology Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, China [2]University of Chinese Academy of Sciences, Beijing, 100049, China [3]State Key Laboratory of Biotherapy and Cancer Center, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China

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关键词： Dendrobium chrysotoxum Lindl Orchidaceae Spirophenanthrene Diphenanthrene Cytotoxic activity Anti-Pulmonary fibrosis activity

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The stems of Dendrobium chrysotoxum Lindl are used as medicinal herbs and for nutraceutical beverages and functional food products. In order to obtain an in-depth understanding of the bioactive compounds in the stems of D. chrysotoxum Lindl, an exhaustive chemical examination was carried out. A total of 20 undescribed compounds (1-20) along with 40 known ones (21-60) were isolated. The structures of 1-20 were elucidated based on spectroscopic analysis and theoretical quantum calculations. The unreported compounds consist of 7 spirophenanthrenes (1-7), 4 diphenanthrenes (8-11), 1 9,10-dihydrophenanthrene derivative (12), 1 phenanthropyran (13), 2 monophenanthrenes (14 and 15), 1 dimeric bibenzyl (16), and 3 bibenzyls (17-20). Six compounds 1b, 3b, 4a, 4b, 8, and 16 exhibited remarkable cytotoxic activity against HCCLM3 cancer cells with IC50 values of 1.68 μM-6.60 μM. Compounds 10, 15, and fimbriadimerbibenzyl D displayed significant anti-pulmonary fibrosis with IC50 values of 1.82 ± 0.02 μM to 3.68 ± 0.03 μM.Copyright © 2025 Elsevier Ltd. All rights reserved.

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大类 | 2 区生物学

小类 | 2 区生化与分子生物学 2 区植物科学

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大类 | 2 区生物学

小类 | 2 区生化与分子生物学 2 区植物科学

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第一作者机构： [1]Key Laboratory of Environmental and Applied Microbiology, Environmental Microbiology Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, China [2]University of Chinese Academy of Sciences, Beijing, 100049, China

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