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Bacteria Flagella-Mimicking Polymer Multilayer Magnetic Microrobots

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机构: [1]First Affiliated Hosp Harbin Med Univ, Affiliated Hosp 1, Harbin 150001, Peoples R China [2]Harbin Inst Technol, Sch Med & Hlth, Harbin 150006, Peoples R China [3]Harbin Inst Technol, State Key Lab Robot & Syst, Harbin 150006, Peoples R China [4]Harbin Med Univ, Canc Hosp, Dept Gastrointestinal Med Oncol, Harbin 150081, Peoples R China [5]Chinese Acad Med Sci, China Japan Friendship Hosp, Ctr Resp Med, State Key Lab Resp Hlth & Multimorbid,Dept Pulm &, Beijing 100029, Peoples R China [6]Harbin Med Univ, Affiliated Hosp 4, Harbin 150001, Peoples R China [7]Sichuan Agr Univ, Coll Environm Sci, Chengdu 611130, Peoples R China [8]Peking Univ, Coll Engn, Dept Adv Mfg & Robot, Beijing, Peoples R China [9]Peking Univ, State Key Lab Turbulence & Complex Syst, Beijing 100091, Peoples R China [10]Imperial Coll London, Dept Math, London SW7 2AZ, England [11]Lomonosov Moscow State Univ, Fac Phys, Magnetism Dept, Moscow 119991, Russia
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关键词: bacteria flagella layer-by-layer technique magnetic field magnetic microrobot self-propulsion

摘要:
Mass production of biomedical microrobots demands expensive and complex preparation techniques and versatile biocompatible materials. Learning from natural bacteria flagella, the study demonstrates a magnetic polymer multilayer cylindrical microrobot that bestows the controllable propulsion upon an external rotating magnetic field with uniform intensity. The magnetic microrobots are constructed by template-assisted layer-by-layer technique and subsequent functionalization of magnetic particles onto the large opening of the microrobots. Geometric variables of the polymer microrobots, such as the diameter and wall thickness, can be controlled by selection of porous template and layers of assembly. The microrobots perform controllable propulsion through the manipulation of magnetic field. The comparative analysis of the movement behavior reveals that the deformation of microrobots may be attributed to the propulsion upon rotating magnetic field, which is similar to that of natural bacteria. The influence of actuation and frequency on the velocity of the microrobots is studied. Such polymer multilayer magnetic microrobots may provide a novel concept to develop rapidly delivering drug therapeutic agents for diverse practical biomedical uses.

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大类 | 2 区 材料科学
小类 | 2 区 物理化学 2 区 材料科学:综合 3 区 纳米科技
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Q1 CHEMISTRY, PHYSICAL Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Q1 NANOSCIENCE & NANOTECHNOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2024版] 出版当年五年平均 出版前一年[2024版]

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第一作者机构: [1]First Affiliated Hosp Harbin Med Univ, Affiliated Hosp 1, Harbin 150001, Peoples R China [2]Harbin Inst Technol, Sch Med & Hlth, Harbin 150006, Peoples R China [3]Harbin Inst Technol, State Key Lab Robot & Syst, Harbin 150006, Peoples R China
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通讯机构: [1]First Affiliated Hosp Harbin Med Univ, Affiliated Hosp 1, Harbin 150001, Peoples R China [2]Harbin Inst Technol, Sch Med & Hlth, Harbin 150006, Peoples R China [3]Harbin Inst Technol, State Key Lab Robot & Syst, Harbin 150006, Peoples R China
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