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A pan-cancer analysis of the oncogenic and immunological roles of transglutaminase 1 (TGM1) in human cancer

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机构： [1]Department of Urology, Institute of Urology, West China School of Medicine, West China Hospital, Sichuan University, Chengdu 610041, China [2]Research Core Facilities, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, People’s Republic of China [3]Department of Urology, The Second Afliated Hospital of Anhui Medical University, Hefei 230601, China [4]Department of Rehabilitation, West Kyushu University, Fukuoka, Japan [5]Department of Urology, Kyung Hee University, Seoul, South Korea [6]Department of Rehabilitation, The Afliated Hospital of Southwest Medical University, Luzhou 646000, People’s Republic of China

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关键词： Pan-cancer biomarker Tumor-infltrating cells Transglutaminase 1

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There is currently a limited number of studies on transglutaminase type 1 (TGM1) in tumors. The objective of this study is to perform a comprehensive analysis across various types of cancer to determine the prognostic significance of TGM1 in tumors and investigate its role in the immune environment.Pan-cancer and mutational data were retrieved from the TCGA database and analyzed using R (version 3.6.4) and its associated software package. The expression difference and prognosis of TGM1 were examined, along with its correlation with tumor heterogeneity, stemness, mutation landscape, and RNA modification. Additionally, the relationship between TGM1 expression and tumor immunity was investigated using the TIMER method.TGM1 is expressed differently in various tumors and normal samples and is associated with the overall survival and progression-free time of KIRC, ACC, SKCM, LIHC, and STES. In LICH, we found a negative correlation between TGM1 expression and 6 indicators of tumor stemness. The mutation frequencies of BLCA, LIHC, and KIRC were 1.7%, 0.3%, and 0.3% respectively. In BLCA and BRCA, there was a significant correlation between TGM1 expression and the infiltration of CD4 + T cells, CD8 + T cells, neutrophils, and dendritic cells.TGM1 has the potential to serve as both a prognostic marker and a drug target.© 2024. The Author(s).

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大类 | 3 区医学

小类 | 4 区肿瘤学

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第一作者机构： [1]Department of Urology, Institute of Urology, West China School of Medicine, West China Hospital, Sichuan University, Chengdu 610041, China

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通讯机构： [1]Department of Urology, Institute of Urology, West China School of Medicine, West China Hospital, Sichuan University, Chengdu 610041, China [6]Department of Rehabilitation, The Afliated Hospital of Southwest Medical University, Luzhou 646000, People’s Republic of China

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