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Comprehensive pan-cancer analysis identifies PLAG1 as a key regulator of tumor immune microenvironment and prognostic biomarker

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机构： [1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China, [2]Division of Surgery and Interventional Science, University College London, London, United Kingdom, [3]Research Core Facilities, West China Hospital, Sichuan University, Chengdu, Sichuan, China, [4]Department of Pathology, Ningbo Clinical Pathology Diagnosis Center, Ningbo, Zhejiang, China

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关键词： pan-cancer analysis pleomorphic adenoma gene 1 biomarker tumor-infiltrating cells tumor microenvironment

摘要：

The literature on the role of pleomorphic adenoma gene 1 (PLAG1) in malignant tumors is limited. This study aimed to perform pan-cancer analysis of PLAG1.The expression of PLAG1 was analyzed by Human Protein Atlas (HPA). The differential expression and prognosis of PLAG1 were analyzed based on TCGA pan-cancer data. The relationship between PLAG1 expression and tumor heterogeneity, stemness and immune infiltration was investigated. The enrichment analysis and biological function of PLAG1 in bladder cancer were analyzed.The expression of PLAG1 was increased in a variety of tumors and significantly correlated with the prognosis of patients. Their expression levels were associated with key immune checkpoint genes (CD274, HAVCR2), immune infiltration and immune stimulation factors (CD48, CD27). In bladder cancer, functional enrichment analysis indicated that PLAG1 was involved in epidermal related processes and immune pathways. PLAG1 gene expression reduction can significantly inhibit the proliferation of bladder cancer cells.PLAG1 has the potential to be a prognostic marker and a potential therapeutic target for patients with malignant tumors.Copyright © 2025 Wu, Li, Zhang, Wang, Yu, Feng and Han.

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出版当年[2025]版：

大类 | 2 区医学

小类 | 2 区免疫学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区免疫学

第一作者：

第一作者机构： [1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China, [2]Division of Surgery and Interventional Science, University College London, London, United Kingdom,

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通讯机构： [1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China, [2]Division of Surgery and Interventional Science, University College London, London, United Kingdom,

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Comprehensive pan-cancer analysis identifies PLAG1 as a key regulator of tumor immune microenvironment and prognostic biomarker

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