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Unlocking the potential of oncology biomarkers: advancements in clinical theranostics

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机构: [1]Joint Laboratory of Artificial Intelligence for Critical Care Medicine, Department of Critical Care Medicine and Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, P.R. China [2]iGlobal Research and Publishing Foundation, New Delhi, India [3]Chitkara College of Pharmacy, Chitkara University Punjab, Rajpura, India [4]Jan Nayak Ch. Devi Lal Memorial College of Pharmacy, Sirsa, Haryana, India [5]Amity Institute of Molecular Medicine & Stem Cell Research, Amity University, Sector-125, Noida, India [6]Department of Pharmaceutical Sciences and Drug Research, Punjabi University Patiala, Patiala, India [7]Amity Institute of Pharmacy, Amity University, Noida, India [8]Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India [9]Department of Pharmaceutics, Delhi Pharmaceutical Sciences and Research University, PushpVihar, Govt. of NCT of Delhi, New Delhi, India [10]Centre for Advanced Formulation and Technology (CAFT), Delhi Pharmaceutical Sciences and Research University, PushpVihar, Govt. of NCT of Delhi, New Delhi, India [11]ER Stress and Mucosal Immunology Lab, School of Health Sciences, University of Tasmania, Launceston, Tasmania, Australia [12]and School of Medicine, University of California San Francisco, San Francisco, CA, USA [13]School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India [14]Department of Rasa Shastra and Bhaishajya Kalpana, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
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关键词: cancer biomarkers diagnostics prognosis epidemiology cancer screening personalized approach

摘要:
Cancer biomarkers have revolutionized the field of oncology by providing valuable insights into tumor changes and aiding in screening, diagnosis, prognosis, treatment prediction, and risk assessment. The emergence of "omic" technologies has enabled biomarkers to become reliable and accurate predictors of outcomes during cancer treatment.In this review, we highlight the clinical utility of biomarkers in cancer identification and motivate researchers to establish a personalized/precision approach in oncology. By extending a multidisciplinary technology-based approach, biomarkers offer an alternative to traditional techniques, fulfilling the goal of cancer therapeutics to find a needle in a haystack.We target different forms of cancer to establish a dynamic role of biomarkers in understanding the spectrum of malignancies and their biochemical and molecular characterization, emphasizing their prospective contribution to cancer screening. Biomarkers offer a promising avenue for the early detection of human cancers and the exploration of novel technologies to predict disease severity, facilitating maximum survival and minimum mortality rates. This review provides a comprehensive overview of the potential of biomarkers in oncology and highlights their prospects in advancing cancer diagnosis and treatment.© 2024 Walter de Gruyter GmbH, Berlin/Boston.

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第一作者机构: [1]Joint Laboratory of Artificial Intelligence for Critical Care Medicine, Department of Critical Care Medicine and Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, P.R. China [2]iGlobal Research and Publishing Foundation, New Delhi, India
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通讯机构: [1]Joint Laboratory of Artificial Intelligence for Critical Care Medicine, Department of Critical Care Medicine and Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, P.R. China [13]School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India [14]Department of Rasa Shastra and Bhaishajya Kalpana, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
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