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Potential molecular biomarkers for the diagnosis and prognosis of bladder cancer

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机构： [1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China [2]West China School of Medicine, Sichuan University, Chengdu, China [3]Out-patient Department, West China Hospital, Sichuan University, Chengdu, China [4]Research Core Facility, West China Hospital, Sichuan University, Chengdu, China.

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关键词： Bladder cancer Molecular biomarkers Molecular subtyping Diagnosis Prognosis

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Bladder cancer (BC) is a common malignant tumor of urinary system, which can be divided into muscle-invasive BC (MIBC) and nonmuscle-invasive BC (NMIBC). The number of BC patients has been gradually increasing currently. At present, bladder tumours are diagnosed and followed-up using a combination of cystoscopic examination, cytology and histology. However, the detection of early grade tumors, which is much easier to treat effectively than advanced stage disease, is still insufficient. It frequently recurs and can progress when not expeditiously diagnosed and monitored following initial therapy for NMIBC. Treatment strategies are totally different for different stage diseases. Therefore, it is of great practical significance to study new biomarkers for diagnosis and prognosis. In this review, we summarize the current state of biomarker development in BC diagnosis and prognosis prediction. We retrospectively analyse eight diagnostic biomarkers and eight prognostic biomarkers, in which CK, P53, PPARγ, PTEN and ncRNA are emphasized for discussion. Eight molecular subtype systems are also identified. Clinical translation of biomarkers for diagnosis, prognosis, monitoring and treatment will hopefully improve outcomes for patients. These potential biomarkers provide an opportunity to diagnose tumors earlier and with greater accuracy, and help identify those patients most at risk of disease recurrence.Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

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大类 | 2 区

医学

小类 | 1 区药学 2 区医学：研究与实验

第一作者：

第一作者机构： [1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China [2]West China School of Medicine, Sichuan University, Chengdu, China

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通讯机构： [1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China [*1]Department of Urology, West China Hospital, Sichuan University, No. 37, Guoxue Alley, Chengdu, Sichuan 610041, PR China

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