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FJX1 as a candidate diagnostic and prognostic serum biomarker for colorectal cancer.

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收录情况： ◇ SCIE

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机构： [1]Medical Research Center, The Third People’s Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, 29 Xifu North Street, Chengdu 610031, Sichuan, China [2]Department of Radiation Oncology, School of Medicine, University of Electronic Science and Technology of China, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, Radiation Oncology Key Laboratory of Sichuan Province, Chengdu 610042, Sichuan, China [3]Department of General Surgery, The 77th Army Hospital, Leshan 614000, Sichuan, China [4]Department of Gastroenterology, The Third People’s Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, 82 Qinglong Road, Chengdu 610031, Sichuan, China [5]Southwest Jiaotong University College of Medicine, Southwest Jiaotong University Affiliated Chengdu Third People’s Hospital, Chengdu 610036, Sichuan, China [6]Department of Laboratory, 363 Hospital, Chengdu 610041, Sichuan, China [7]Department of Clinical Laboratory, The Second Affiliated Hospital of Chengdu Medical College (China National Nuclear Corporation 416 Hospital), Chengdu 610051, Sichuan, China

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关键词： Colorectal cancer Diagnosis Prognosis Serum biomarkers

摘要：

Colorectal cancer (CRC) is one of the most common cancer worldwide. It is essential to identify non-invasive diagnostic and prognostic biomarkers of CRC. The aim of the present study was to screen candidate biomarkers in diagnosis and prognosis of CRC based on a novel strategy.The expression level of gene higher in cancer than in adjacent non-cancer tissue was defined as "positive", and the top 10% genes with "positive rate" were filtered out as candidate diagnostic biomarkers in four Gene Expression Omnibus (GEO) datasets. Then, the prognostic value of candidate biomarkers was estimated Cox regression analysis. Moreover, the concentration of biomarker in serum was detected in CRC patients.Eighteen candidate biomarkers were identified with efficient diagnostic value in CRC. As a prognostic biomarker, FJX1 (four-jointed box kinase 1) showed a good performance in predicting overall survivals in CRC patients. In serum levels, FJX1 showed high sensitivity and specificity in distinguishing CRC patients from controls, and the concentration of serum FJX1 was associated with distant metastasis in CRC. In addition, serum FJX1 was significantly decreased after surgery in CRC patients. Compared with traditional CRC biomarkers CEA and CA 19-9, FJX1 still showed good efficiency in diagnosis and prognosis. Moreover, inhibition of FJX1 expression by siRNA or neutralization of secreted FJX1 by antibody could suppress cell proliferation and migration in vitro.Our findings provided a novel strategy to identify diagnostic biomarkers based on public datasets, and suggested that FJX1 was a candidate diagnostic and prognostic biomarker in CRC patients.© 2022. The Author(s), under exclusive licence to Federación de Sociedades Españolas de Oncología (FESEO).

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出版当年[2022]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

最新[2023]版：

大类 | 3 区医学

小类 | 4 区肿瘤学

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出版当年[2022]版：

Q3 ONCOLOGY

最新[2023]版：

Q2 ONCOLOGY

影响因子： 2.8 最新[2023版] 2.9 最新五年平均 3.4 出版当年[2022版] 3.1 出版当年五年平均 3.34 出版前一年[2021版] 2.8 出版后一年[2023版]

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第一作者机构： [1]Medical Research Center, The Third People’s Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, 29 Xifu North Street, Chengdu 610031, Sichuan, China

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FJX1 as a candidate diagnostic and prognostic serum biomarker for colorectal cancer.

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