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Crucial role of the transcription factors family activator protein 2 in cancer: current clue and views

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收录情况： ◇ SCIE

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机构： [1]Department of Cardiothoracic Surgery, The First Afliated Hospital of Chongqing Medical University, Chongqing, China [2]University Medical Center Göttingen, University of Göttingen, Göttingen, Germany [3]Target Discovery Institute, Centre for Medicines Discovery, Nufeld Department of Medicine, University of Oxford, Chinese Academy for Medical Sciences Oxford Institute, Oxford, UK [4]Department of Urology, Churchill Hospital, Oxford University Hospitals NHS Foundation, Oxford, UK [5]Department of Experimental Surgery, Medical University of Lodz, Lodz, Poland [6]Department of General Surgery & Laboratory of Gastric Cancer, State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China [7]Gastric Cancer Center, West China Hospital, Sichuan University, Chengdu, China [8]Department of Neurology, West China Hospital, Sichuan University, Chengdu, China [9]Institute of Brain Science and Brain-Inspired Technology, West China Hospital, Sichuan University, Chengdu, China [10]Department of Liver Surgery, West China Hospital, Sichuan University, Chengdu, China

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关键词： Activator protein 2 Transcription factor Cancer stemness Epithelial-mesenchymal transition Tumor microenvironment Ferroptosis

摘要：

The transcription factor family activator protein 2 (TFAP2) is vital for regulating both embryonic and oncogenic development. The TFAP2 family consists of five DNA-binding proteins, including TFAP2A, TFAP2B, TFAP2C, TFAP2D and TFAP2E. The importance of TFAP2 in tumor biology is becoming more widely recognized. While TFAP2D is not well studied, here, we mainly focus on the other four TFAP2 members. As a transcription factor, TFAP2 regulates the downstream targets directly by binding to their regulatory region. In addition, the regulation of downstream targets by epigenetic modification, posttranslational regulation, and interaction with noncoding RNA have also been identified. According to the pathways in which the downstream targets are involved in, the regulatory effects of TFAP2 on tumorigenesis are generally summarized as follows: stemness and EMT, interaction between TFAP2 and tumor microenvironment, cell cycle and DNA damage repair, ER- and ERBB2-related signaling pathway, ferroptosis and therapeutic response. Moreover, the factors that affect TFAP2 expression in oncogenesis are also summarized. Here, we review and discuss the most recent studies on TFAP2 and its effects on carcinogenesis and regulatory mechanisms.© 2023. The Author(s).

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出版当年[2023]版：

大类 | 2 区

医学

小类 | 2 区医学：研究与实验

最新[2023]版：

大类 | 2 区

医学

小类 | 2 区医学：研究与实验

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出版当年[2023]版：

Q1 MEDICINE, RESEARCH & EXPERIMENTAL

最新[2023]版：

Q1 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 6.1 最新[2023版] 6.2 最新五年平均 6.1 出版当年[2023版] 6.2 出版当年五年平均 7.4 出版前一年[2022版]

第一作者：

第一作者机构： [1]Department of Cardiothoracic Surgery, The First Afliated Hospital of Chongqing Medical University, Chongqing, China [10]Department of Liver Surgery, West China Hospital, Sichuan University, Chengdu, China

通讯作者：

通讯机构： [6]Department of General Surgery & Laboratory of Gastric Cancer, State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China [7]Gastric Cancer Center, West China Hospital, Sichuan University, Chengdu, China [8]Department of Neurology, West China Hospital, Sichuan University, Chengdu, China [9]Institute of Brain Science and Brain-Inspired Technology, West China Hospital, Sichuan University, Chengdu, China

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Crucial role of the transcription factors family activator protein 2 in cancer: current clue and views

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