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The tumor-repressing effect of CYP27A1 on renal cell carcinoma by 27-HC arising from cholesterol metabolism

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机构： [1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China [2]Department of Pathology, West China Hospital, Sichuan University, Chengdu, China

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关键词： 27-HC apoptosis CDKN1B c-IAP2 CYP27A1 RCC TNFR1

摘要：

As a key approach to mediate cholesterol metabolism, the role of the CYP27A1/27-HC axis in renal cell carcinoma (RCC) remains unclear. Analysis of CYP27A1 expression from public databases and metastatic cases in our center suggested that CYP27A1 was obviously downregulated in RCC tissues, and survival analysis further showed its correlation with favorable clinicopathological features and prognosis. In vitro, up and downregulation of CYP27A1 expression in RCC cell lines could definitely illustrate its anticipation involving apoptosis, proliferation, invasion, migration, and clonality. This could be achieved through upregulation of 27-HC concentration, which mediates the activation of signaling pathways of apoptosis and cell cycle arrest. Further, recovery of CYP27A1 expression could definitely inhibit the proliferation of RCC tumors in vivo. This is the first study to explore the role of the CYP27A1/27-HC axis in RCC. Attempts to maintain the normal function of the axis may be a potential strategy in the treatment of RCC, and the predictive value of CYP27A1 detection on the efficacy of targeted therapy in metastatic RCC is also worthy of attention.© 2022 Federation of American Societies for Experimental Biology.

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出版当年[2022]版：

大类 | 2 区

生物学

小类 | 2 区生物学 2 区生化与分子生物学 3 区细胞生物学

最新[2023]版：

大类 | 2 区

生物学

小类 | 2 区生化与分子生物学 2 区生物学 3 区细胞生物学

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第一作者机构： [1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China

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通讯机构： [1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China [*1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, No.37 Guoxue Alley, Wuhou District, Chengdu City, Sichuan Province, China.

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