Triarylboron-Based High Photosensitive Probes for Apoptosis Detection, Tumor-Targeted Imaging, and Selectively Inducing Apoptosis of Tumor Cells by Photodynamics.
机构：[1]School of Pharmacy and Institute of Pharmacy, North Sichuan Medical College, Sichuan 637100, China.[2]Thyroid and Breast Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, People's Republic of China.[3]Institute of Chemistry & University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100190, China.[4]College of Chemistry and Chemical Engineering & Chongqing Key Laboratory of Theoretical and Computational Chemistry, Chongqing University, Chongqing 401331, China.
Herein, a series of triarylboron-based fluorescent probes were developed for distinguishing apoptosis from living cells and even necrosis. They also demonstrate high photosensitivity because they can produce detectable reactive oxygen species (ROS) under an ultra-low light power density (1.5 mW/cm2). By changing the peripheral groups to regulate the performance, we identified a multifunctional probe, TAB-6-amyl, which can be used not only for selectively imaging apoptosis but also for the targeted imaging of SKOV-3 cells in vitro and in vivo. It could further specifically induce the apoptosis of SKOV-3 cells under light irradiation. During the study, we also found that TAB-6-amyl can cross the blood-brain barrier (BBB). Therefore, another probe based on this kind of structure, TAB-5-M-1-cRGD, was constructed for the targeted imaging of brain glioma cells and inducing their apoptosis. This study offers some promising tools for apoptosis detection and tumor photodynamic therapy (PDT).
基金：
National Natural Science Foundation of
China (Nos. 81801768, 32171919, and 82104116), the Special
Projects of Central Government Guiding Development of
Local Science and Technology (Nos. 2021ZYD0065 and
2021ZYD0051), “Government-Universities” Specific Cooperative
Scientific Research Project of Nanchong (Nos.
20SXCXTD0003 and 20SXQT0192), and the North Sichuan
Medical College (CBY19-YZ04).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类|1 区化学
小类|1 区分析化学
最新[2023]版：
大类|1 区化学
小类|1 区分析化学
第一作者：
第一作者机构：[1]School of Pharmacy and Institute of Pharmacy, North Sichuan Medical College, Sichuan 637100, China.[*1]School of Pharmacy and Institute of Pharmacy, North Sichuan Medical College, Sichuan 637100, China
共同第一作者：
通讯作者：
通讯机构：[1]School of Pharmacy and Institute of Pharmacy, North Sichuan Medical College, Sichuan 637100, China.[4]College of Chemistry and Chemical Engineering & Chongqing Key Laboratory of Theoretical and Computational Chemistry, Chongqing University, Chongqing 401331, China.[*1]School of Pharmacy and Institute of Pharmacy, North Sichuan Medical College, Sichuan 637100, China[*2]College of Chemistry and Chemical Engineering & Chongqing Key Laboratory of Theoretical and Computational Chemistry, Chongqing University, Chongqing 401331, China
推荐引用方式(GB/T 7714)：
Liu Jun,Chen Hongyu,Wang Bing,et al.Triarylboron-Based High Photosensitive Probes for Apoptosis Detection, Tumor-Targeted Imaging, and Selectively Inducing Apoptosis of Tumor Cells by Photodynamics.[J].Analytical chemistry.2022,doi:10.1021/acs.analchem.2c01364.
APA：
Liu Jun,Chen Hongyu,Wang Bing,Luo Yingping,Yang Guoqiang...&Li Shayu.(2022).Triarylboron-Based High Photosensitive Probes for Apoptosis Detection, Tumor-Targeted Imaging, and Selectively Inducing Apoptosis of Tumor Cells by Photodynamics..Analytical chemistry,,
MLA：
Liu Jun,et al."Triarylboron-Based High Photosensitive Probes for Apoptosis Detection, Tumor-Targeted Imaging, and Selectively Inducing Apoptosis of Tumor Cells by Photodynamics.".Analytical chemistry .(2022)
化学