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A pilot study of [68Ga]Ga-FAPI-04 PET/CT in renal cell carcinoma

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资源类型：
Pubmed体系：
作者：
Guo Chunmei[1,2,3] ; Liu Ya[1,2,3] ; Yang Haozhou[4] ; Xia Yuxiao[5] ; Li Xue[1,2,3] ; Chen Liming[1,2,3] ; Feng Yue[1,2,3] ; Zhang Yan[1,2,3] ; Chen Yue[1,2,3] ; Huang Zhanwen[1,2,3,*1] ;
机构： [1]Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, China. [2]Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, China. [3]Institute of Nuclear Medicine, Southwest Medical University, Luzhou, China. [4]Department of Urology, Fushun People's Hospital, Zigong, China. [5]Department of Nuclear Medicine, Second Affiliated Hospital of Chengdu Medical College (China National Nuclear Corporation 416 Hospital), Chengdu, China.
出处：
DOI： 10.1093/bjr/tqae025
ISSN：

关键词： PET/CT [68Ga]Ga-FAPI-04 [18F]FDG RCC

摘要：
As a promising positron emission tomography (PET) tracer, [68Ga]Ga-fibroblast activation protein inhibitor-04([68Ga]Ga-FAPI-04) performs better than 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) at diagnosing primary and metastatic lesions in patients with various types of cancer. We investigated the utility of [68Ga]Ga-FAPI-04 PET/CT for the detection of primary and metastatic lesions in renal cell carcinoma (RCC). [18F]FDG PET/CT were used for comparison.Twenty-two patients with suspected RCC or recurrent RCC were enrolled in our study. Among these patients, 14 were newly diagnosed with RCC, 3 had recurrent RCC, and 5 were excluded from further analysis due to having benign renal tumours. Seventeen patients with RCC underwent [68Ga]Ga-FAPI-04 PET/CT, and 6 of them also received [18F]FDG PET/CT. The positive detection rates were calculated and compared with those in patients who underwent both scans.Data from 17 patients with RCC (median age: 60.5 years, interquartile range [IQR]: 54-70 years) were evaluated. The positive detection rate of [68Ga]Ga-FAPI-04 PET/CT for RCC was 64.7% (11/17). Lymph node metastases (n = 44), lung metastasis (n = 1), and bone metastasis (n = 1) were detected. Six patients with RCC underwent [68Ga]Ga-FAPI-04 and [18F]FDG PET/CT. [68Ga]Ga-FAPI-04 PET/CT showed a higher positive detection rate than [18F]FDG PET/CT in detecting RCC (83.3% [5/6] vs. 50% [3/6], P = 0.545). Additionally, [68Ga]Ga-FAPI-04 PET/CT has higher SUVmax (3.20 [IQR: 2.91-5.80 vs. 2.71 [IQR: 2.13-3.10], p = 0.116) and TBR values (1.60 [IQR: 1.33-3.67] vs. 0.86 [0.48-1.21], p = 0.028) than [18F]FDG PET/CT.These findings suggest that [68Ga]Ga-FAPI-04 PET/CT has potential value in RCC diagnosis. Further studies are warranted to validate these results.Clinical utility of [68Ga]Ga-FAPI-04 in RCC remains unclear, and there aren't many similar studies in the literature. We evaluated the role of [68Ga]Ga-FAPI-04 in diagnosing RCC.© The Author(s) 2024. Published by Oxford University Press on behalf of the British Institute of Radiology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

基金：
This work was supported by Young Talent Program of China National Nuclear Corporation (CNNC2021137); Sichuan Science and Technology Innovation and Entrepreneurship Seedling Project (2021JDRC0170); Natural Science Foundation of Chengdu Medical College (CYZYB20-14); China Baoyuan Research Fund (CBYI202105); and Sichuan Provincial Medical Youth Innovation Research (Q21076).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 4 区 医学
小类 | 4 区 核医学
最新[2023]版：
大类 | 4 区 医学
小类 | 4 区 核医学
第一作者：
第一作者机构： [1]Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, China. [2]Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, China. [3]Institute of Nuclear Medicine, Southwest Medical University, Luzhou, China.
通讯作者：
通讯机构： [1]Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, China. [2]Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, China. [3]Institute of Nuclear Medicine, Southwest Medical University, Luzhou, China. [*1]partment of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China
推荐引用方式(GB/T 7714)：
Guo Chunmei,Liu Ya,Yang Haozhou,et al.A pilot study of [68Ga]Ga-FAPI-04 PET/CT in renal cell carcinoma[J].The British Journal Of Radiology.2024,doi:10.1093/bjr/tqae025.
APA：
Guo Chunmei,Liu Ya,Yang Haozhou,Xia Yuxiao,Li Xue...&Huang Zhanwen.(2024).A pilot study of [68Ga]Ga-FAPI-04 PET/CT in renal cell carcinoma.The British Journal Of Radiology,,
MLA：
Guo Chunmei,et al."A pilot study of [68Ga]Ga-FAPI-04 PET/CT in renal cell carcinoma".The British Journal Of Radiology .(2024)

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