个人中心| | 帮助
高级检索
当前位置： 首页 > 详情页

MicroRNA-1 promotes apoptosis of hepatocarcinoma cells by targeting apoptosis inhibitor-5 (API-5).

| 认领 | 导出 | |

文献详情

资源类型：
Pubmed体系：
作者：
Dong Li[a] ; Yu Liu[a] ; Hua Li[a] ; Jing-Jing Peng[a] ; Yan Tan[b] ; Qiang Zou[c] ; Xiao-Feng Song[d] ; Min Du[a] ; Zheng-Hui Yang[e] ; Yong Tan[a] ; Jin-Jun Zhou[a] ; Tao Xu[a] ; Zeng-Qiang Fu[a] ; Jian-Qiong Feng[a] ; Peng Cheng[a] ; Tao chen[a] ; Dong Wei[a] ; Xiao-Mei Su[a] ; Huan-Yi Liu[a] ; Zhong-Chun Qi[a] ; Li-Jun Tang[f] ; Tao Wang[f] ; Xin Guo[g] ; Yong-He Hu[a,*1] ; Tao Zhang[a,*2] ;
机构： [a]Department of Oncology, Chengdu Military General Hospital, Chengdu 610083, Sichuan Province, China [b]Department of Scientific Research and Training, Chengdu Military General Hospital, Chengdu 610083, Sichuan Province, China [c]Institute of Aging and Immunity, Chengdu Medical College, Chengdu 610083, Sichuan Province, China [d]Department of Health Care, Chengdu Military General Hospital, Chengdu 610083, Sichuan Province, China [e]Department of Neurology, Chengdu Military General Hospital, Chengdu 610083, Sichuan Province, China [f]Department of General Surgery, Chengdu Military General Hospital, Chengdu 610083, Sichuan Province, China [g]Department of Medical Lab, Chengdu Military General Hospital, Chengdu 610083, Sichuan Province, China
出处：
DOI： 10.1016/j.febslet.2014.11.025
ISSN：

关键词： microRNA-1 Apoptosis inhibitor 5 Apoptosis Hepatocellular carcinoma Hepatoma cell

摘要：
Although microRNA-1 (miR-1) is a known liver cancer suppressor, the role of miR-1 in apoptosis of hepatoma cells has remained largely unknown. Our study shows that ectopic miR-1 overexpression induced apoptosis of liver hepatocellular carcinoma (HepG2) cells. Apoptosis inhibitor 5 (API-5) was found to be a potential regulator of miR-1 induced apoptosis, using a bioinformatics approach. Furthermore, an inverse relationship between miR-1 and API-5 expression was observed in human liver cancer tissues and adjacent normal liver tissues. Negative regulation of API-5 expression by miR-1 was demonstrated to promote apoptosis of HepG2 cells. Our study provides a novel regulatory mechanism of miR-1 in the apoptosis of hepatoma cells. Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

基金：
This work was supported by the National Natural Science Foundation of China (Grant 81101634), the Scientific Research Foundation of the Science and Technology Department of Sichuan Province (Grants 2012SZ0058 and 2012JY0031), the Scientific Research Project of the Health Department of Sichuan Province (Nos. 110472 and 110478), the Key Project of Medical Science and Technology of Chengdu Military Region during the 12th Five- Year Plan (Nos. B12018 and B14005) and the Scientific Research Project of the Administration of Traditional Chinese Medicine of Sichuan Province (No. 2014K057).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类 | 3 区 生物
小类 | 3 区 生化与分子生物学 3 区 生物物理 4 区 细胞生物学
最新[2023]版：
大类 | 4 区 生物学
小类 | 4 区 生化与分子生物学 4 区 生物物理 4 区 细胞生物学
第一作者：
第一作者机构： [a]Department of Oncology, Chengdu Military General Hospital, Chengdu 610083, Sichuan Province, China
共同第一作者：
通讯作者：
通讯机构： [a]Department of Oncology, Chengdu Military General Hospital, Chengdu 610083, Sichuan Province, China [*1]Chengdu Military General Hospital, No. 270, Rongdu Avenue, Jinniu District, Chengdu, Sichuan Province 610083, China. [*2]Department of Oncology, Chengdu Military General Hospital, No. 270, Rongdu Avenue, Jinniu District, Chengdu, Sichuan Province 610083, China.
推荐引用方式(GB/T 7714)：
Dong Li,Yu Liu,Hua Li,et al.MicroRNA-1 promotes apoptosis of hepatocarcinoma cells by targeting apoptosis inhibitor-5 (API-5).[J].FEBS letters.2015,589(1):68-76.doi:10.1016/j.febslet.2014.11.025.
APA：
Dong Li,Yu Liu,Hua Li,Jing-Jing Peng,Yan Tan...&Tao Zhang.(2015).MicroRNA-1 promotes apoptosis of hepatocarcinoma cells by targeting apoptosis inhibitor-5 (API-5)..FEBS letters,589,(1)
MLA：
Dong Li,et al."MicroRNA-1 promotes apoptosis of hepatocarcinoma cells by targeting apoptosis inhibitor-5 (API-5).".FEBS letters 589..1(2015):68-76

相关文献

[1]The novel proteasome inhibitor carfilzomib activates and enhances extrinsic apoptosis involving stabilization of death receptor 5. [2]Targeting Pin1 by inhibitor API-1 regulates microRNA biogenesis and suppresses hepatocellular carcinoma development. [3]水杨酸对人肝癌HepG2细胞体外生长的影响的研究* [4]LukS-PV-Regulated MicroRNA-125a-3p Promotes THP-1 Macrophages Differentiation and Apoptosis by Down-Regulating NF1 and Bcl-2 [5]Peroxiredoxin 1 is essential for natamycin-triggered apoptosis and protective autophagy in hepatocellular carcinoma. [6]Sphingosine 1-phosphate regulates proliferation, cell cycle and apoptosis of hepatocellular carcinoma cells via syndecan-1. [7]Aidi injection induces apoptosis of hepatocellular carcinoma cells through the mitochondrial pathway. [8]SOX11 regulates apoptosis and cell cycle in hepatocellular carcinoma via Wnt/β-catenin signaling pathway. [9]Targeted polymeric therapeutic nanoparticles: Design and interactions with hepatocellular carcinoma. [10]NR0B1 augments sorafenib resistance in hepatocellular carcinoma through promoting autophagy and inhibiting apoptosis

资源点击量：46424 今日访问量：0 总访问量：3323 更新日期：2024-11-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 四川省肿瘤医院 技术支持：重庆聚合科技有限公司 地址：成都市人民南路四段55号