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The hepatoprotective effects of plant-based foods based on the "gut-liver axis": a prospective review

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机构: [1]Chengdu Univ Tradit Chinese Med, Sch Pharm, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R China [2]Univ Elect Sci & Technol China, Sch Med, Sichuan Canc Ctr, Sichuan Canc Hosp & Inst,Dept Clin Pharm, Chengdu, Peoples R China [3]Univ Massachusetts, Dept Food Sci, Amherst, MA 01003 USA [4]USDA, Agr Res Serv, Southern Reg Res Ctr, New Orleans, LA USA
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关键词: Liver diseases plant-based foods intestinal mucosal barrier LPS TLR4 pharmacological effects mechanisms

摘要:
The importance of the "gut-liver axis" in the pathogenesis of liver diseases has been revealed recently; which promotes the process of developing preventive and therapeutic strategies. However, considering that there are still many challenges in the medical treatment of liver diseases, potential preventive dietary intervention may be a good alternative choice. Plant-based foods have received much attention due to their reported health-promoting effects in targeting multiple pathways involved in the pathogenesis of liver diseases as well as the relative safety for general use. Based on the PubMed and Web of Science databases, this review emphatically summarizes the plant-based foods and their chemical constituents with reported effects to impact the LPS/TLR4 signaling pathway of gut-liver axis of various liver diseases, reflecting their health benefits in preventing/alleviating liver diseases. Moreover, some plant-based foods with potential gut-liver effects are specifically analyzed from the reported studies and conclusions. This review intends to provide readers an overview of the current progress in the field of this research topic. We expect to see more hepatoprotective measures for alleviating the current prevalence of liver diseases.

基金:

基金编号: 82073994 2020JDJQ0049 2019CC02 2018HH0122 2017-GH02-00054-HZ QJJJ2021002 QNXZ2018026 20191083-127 CRIS 6054-41000-113-00-D

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出版当年[2023]版
大类 | 1 区 农林科学
小类 | 2 区 食品科技 2 区 营养学
最新[2023]版
大类 | 1 区 农林科学
小类 | 2 区 食品科技 2 区 营养学
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出版当年[2023]版:
Q1 FOOD SCIENCE & TECHNOLOGY Q1 NUTRITION & DIETETICS
最新[2023]版:
Q1 FOOD SCIENCE & TECHNOLOGY Q1 NUTRITION & DIETETICS

影响因子: 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2022版]

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第一作者机构: [1]Chengdu Univ Tradit Chinese Med, Sch Pharm, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R China
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