个人中心| | 帮助
高级检索
当前位置： 首页 > 详情页

The Cytosolic DNA-Sensing cGAS-STING Pathway in Liver Diseases.

| 认领 | 导出 | |

文献详情

资源类型：
Pubmed体系：
作者：
Wang Zhilei[1,2,3] ; Chen Nian[3] ; Li Zhiyong[3] ; Xu Guang[2] ; Zhan Xiaoyan[2] ; Tang Jianyuan[1] ; Xiao Xiaohe[2,3,4] ; Bai Zhaofang[2,4] ;
机构： [1]TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China. [2]Department of Liver Diseases, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China. [3]State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China. [4]China Military Institute of Chinese Materia, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China.
出处：
DOI： 10.3389/fcell.2021.717610
ISSN：

关键词： DNA-sensing cyclic GMP-AMP synthase stimulator of interferon genes liver diseases cyclic guanosine monophosphate-adenosine monophosphate

摘要：
Inflammation is regulated by the host and is a protective response activated by the evolutionarily conserved immune system in response to harmful stimuli, such as dead cells or pathogens. cGAS-STING pathway is a vital natural sensor of host immunity that can defend various tissues and organs against pathogenic infection, metabolic syndrome, cellular stress and cancer metastasis. The potential impact of cGAS-STING pathway in hepatic ischemia reperfusion (I/R) injury, alcoholic/non-alcoholic steatohepatitis (ASH), hepatic B virus infection, and other liver diseases has recently attracted widespread attention. In this review, the relationship between cGAS-STING pathway and the pathophysiological mechanisms and progression of liver diseases is summarized. Additionally, we discuss various pharmacological agonists and antagonists of cGAS-STING signaling as novel therapeutics for the treatment of liver diseases. A detailed understanding of mechanisms and biology of this pathway will lay a foundation for the development and clinical application of therapies for related liver diseases.Copyright © 2021 Wang, Chen, Li, Xu, Zhan, Tang, Xiao and Bai.

基金：
National Natural Science Foundation of China (81874368 and 81630100), the National Science and Technology Major Project “Key New Drug Creation and Manufacturing Program” (2017ZX09301022 and 2018ZX09101002-001-002).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类 | 3 区 生物学
小类 | 2 区 发育生物学 3 区 细胞生物学
最新[2023]版：
大类 | 2 区 生物学
小类 | 2 区 发育生物学 3 区 细胞生物学
第一作者：
第一作者机构： [1]TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China. [2]Department of Liver Diseases, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China. [3]State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
共同第一作者：
通讯作者：
通讯机构： [2]Department of Liver Diseases, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China. [3]State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China. [4]China Military Institute of Chinese Materia, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China.
推荐引用方式(GB/T 7714)：
Wang Zhilei,Chen Nian,Li Zhiyong,et al.The Cytosolic DNA-Sensing cGAS-STING Pathway in Liver Diseases.[J].Frontiers in cell and developmental biology.2021,9:717610.doi:10.3389/fcell.2021.717610.
APA：
Wang Zhilei,Chen Nian,Li Zhiyong,Xu Guang,Zhan Xiaoyan...&Bai Zhaofang.(2021).The Cytosolic DNA-Sensing cGAS-STING Pathway in Liver Diseases..Frontiers in cell and developmental biology,9,
MLA：
Wang Zhilei,et al."The Cytosolic DNA-Sensing cGAS-STING Pathway in Liver Diseases.".Frontiers in cell and developmental biology 9.(2021):717610

相关文献

[1]STING信号通路及其功能 [2]Overcome the challenge for intratumoral injection of STING agonist for pancreatic cancer by systemic administration [3]Editorial: Liver diseases and programmed cell death [4]Radiomics in Liver Diseases: Current Progress and Future Opportunities. [5]肝病超声诊断指南 [6]肝病超声诊断指南 [7]肝病超声诊断指南 [8]Identification of an 88-microRNA signature in whole blood for diagnosis of hepatocellular carcinoma and other chronic liver diseases [9]The hepatoprotective effects of plant-based foods based on the "gut-liver axis": a prospective review [10]医院后勤精细化管理策略研究

资源点击量：43370 今日访问量：0 总访问量：3120 更新日期：2024-09-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 四川省肿瘤医院 技术支持：重庆聚合科技有限公司 地址：成都市人民南路四段55号