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Hydroxysafflor yellow A: a natural pigment with potential anticancer therapeutic effect

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机构: [1]Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Department of Pharmacy, West China Hospital, Chengdu, China. [2]Sichuan Province College Key Laboratory of Structure-Specific Small Molecule Drugs, School of Pharmacy, Chengdu Medical College, Institute of Materia Medica, Chengdu, China. [3]Development and Regeneration Key Lab of Sichuan Province, Department of Pathology, Chengdu Medical College, Chengdu, China. [4]Development and Regeneration Key Lab of Sichuan Province, Department of Anatomy and Histology and Embryology, Chengdu Medical College, Chengdu, China.
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关键词: hydroxysafflor yellow A pharmacological effects anticancer effect pharmacokinetic progress safety

摘要:
Hydroxysafflor yellow A (HSYA), a natural pigment with a chalcone structure extracted from Carthamus tinctorius L. (Safflower), has been widely proven to have good efficacy on cardiovascular diseases, atherosclerosis, cancer, and diabetes. However, no study has reported on the anticancer mechanisms of Hydroxysafflor yellow A (HSYA), a principal bioactive compound in safflower. This review discusses recent developments in the physicochemical properties and sources, pharmacological effects and mechanisms, pharmacokinetic progress, and safety of HSYA, focusing on the involvement of HSYA in the regulation of related pathways and mechanisms of apoptosis, autophagy, and the tumor immune microenvironment in a variety of cancers. This can serve as a theoretical basis for further research and development of HSYA, with insights into the mechanisms of anticancer signaling pathways.Copyright © 2025 Wang, An, Zhou, Chang, Zhang and Peng.

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大类 | 2 区 医学
小类 | 2 区 药学
第一作者:
第一作者机构: [1]Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Department of Pharmacy, West China Hospital, Chengdu, China.
通讯作者:
通讯机构: [2]Sichuan Province College Key Laboratory of Structure-Specific Small Molecule Drugs, School of Pharmacy, Chengdu Medical College, Institute of Materia Medica, Chengdu, China. [3]Development and Regeneration Key Lab of Sichuan Province, Department of Pathology, Chengdu Medical College, Chengdu, China. [4]Development and Regeneration Key Lab of Sichuan Province, Department of Anatomy and Histology and Embryology, Chengdu Medical College, Chengdu, China.
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