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Interaction of ncRNA and Epigenetic Modifications in Gastric Cancer: Focus on Histone Modification.

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机构: [1]Department of Oncology, The Affiliated Hospital of Southwest Medical University, Southwest Medical University, Luzhou, China [2]South Sichuan Institute of Translational Medicine, Luzhou, China [3]Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China [4]Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, China [5]School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, Hong Kong SAR, China
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关键词: ncRNA histone modification gastric cancer epigenetic modifications mechanisms

摘要:
Gastric cancer has developed as a very common gastrointestinal tumors, with recent effective advancements in the diagnosis and treatment of early gastric cancer. However, the prognosis for gastric cancer remains poor. As a result, there is in sore need of better understanding the mechanisms of gastric cancer development and progression to improve existing diagnostic and treatment options. In recent years, epigenetics has been recognized as an important contributor on tumor progression. Epigenetic changes in cancer include chromatin remodeling, DNA methylation and histone modifications. An increasing number of studies demonstrated that noncoding RNAs (ncRNAs) are associated with epigenetic changes in gastric cancer. Herein, we describe the molecular interactions of histone modifications and ncRNAs in epigenetics. We focus on ncRNA-mediated histone modifications of gene expression associated with tumorigenesis and progression in gastric cancer. This molecular mechanism will contribute to our deeper understanding of gastric carcinogenesis and progression, thus providing innovations in gastric cancer diagnosis and treatment strategies.Copyright © 2022 Yang, Chen, Guo, Dai, Tang, Zhao, Wu, Li, Du, Shen, Yi, Xiao and Wen.

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出版当年[2021]版:
大类 | 3 区 医学
小类 | 3 区 肿瘤学
最新[2023]版:
大类 | 3 区 医学
小类 | 3 区 肿瘤学
第一作者:
第一作者机构: [1]Department of Oncology, The Affiliated Hospital of Southwest Medical University, Southwest Medical University, Luzhou, China [2]South Sichuan Institute of Translational Medicine, Luzhou, China
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通讯机构: [1]Department of Oncology, The Affiliated Hospital of Southwest Medical University, Southwest Medical University, Luzhou, China [2]South Sichuan Institute of Translational Medicine, Luzhou, China [3]Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China [4]Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, China
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