详情页 - 四川省肿瘤医院知识库

当前位置：首页 > 详情页

Interaction of ncRNA and Epigenetic Modifications in Gastric Cancer: Focus on Histone Modification.

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]Department of Oncology, The Affiliated Hospital of Southwest Medical University, Southwest Medical University, Luzhou, China [2]South Sichuan Institute of Translational Medicine, Luzhou, China [3]Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China [4]Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, China [5]School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, Hong Kong SAR, China

出处：

DOI：

ISSN：

关键词： ncRNA histone modification gastric cancer epigenetic modifications mechanisms

摘要：

Gastric cancer has developed as a very common gastrointestinal tumors, with recent effective advancements in the diagnosis and treatment of early gastric cancer. However, the prognosis for gastric cancer remains poor. As a result, there is in sore need of better understanding the mechanisms of gastric cancer development and progression to improve existing diagnostic and treatment options. In recent years, epigenetics has been recognized as an important contributor on tumor progression. Epigenetic changes in cancer include chromatin remodeling, DNA methylation and histone modifications. An increasing number of studies demonstrated that noncoding RNAs (ncRNAs) are associated with epigenetic changes in gastric cancer. Herein, we describe the molecular interactions of histone modifications and ncRNAs in epigenetics. We focus on ncRNA-mediated histone modifications of gene expression associated with tumorigenesis and progression in gastric cancer. This molecular mechanism will contribute to our deeper understanding of gastric carcinogenesis and progression, thus providing innovations in gastric cancer diagnosis and treatment strategies.Copyright © 2022 Yang, Chen, Guo, Dai, Tang, Zhao, Wu, Li, Du, Shen, Yi, Xiao and Wen.

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2021]版：

大类 | 3 区医学

小类 | 3 区肿瘤学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区肿瘤学

第一作者：

第一作者机构： [1]Department of Oncology, The Affiliated Hospital of Southwest Medical University, Southwest Medical University, Luzhou, China [2]South Sichuan Institute of Translational Medicine, Luzhou, China

共同第一作者：

通讯作者：

通讯机构： [1]Department of Oncology, The Affiliated Hospital of Southwest Medical University, Southwest Medical University, Luzhou, China [2]South Sichuan Institute of Translational Medicine, Luzhou, China [3]Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China [4]Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, China

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Targeting epigenetic modifications in Parkinson's disease therapy [2]Mapping the epigenetic modifications of DNA and RNA. [3]Epigenetic modifications promote the expression of the orphan nuclear receptor NR0B1 in human lung adenocarcinoma cells [4]Histone lysine methacrylation is a dynamic post-translational modification regulated by HAT1 and SIRT2. [5]Management of triple-negative breast cancer by natural compounds through different mechanistic pathways [6]The Role of Epigenetic Modifications in Human Cancers and the Use of Natural Compounds as Epidrugs: Mechanistic Pathways and Pharmacodynamic Actions. [7]Editorial: Epigenetic regulation of genome integrity and its implications in human diseases [8]Coordinating single-cell and bulk RNA-seq in deciphering the intratumoral immune landscape and prognostic stratification of prostate cancer patients [9]Insights into the role of long non-coding RNAs in DNA methylation mediated transcriptional regulation [10]CRC-EBD: Epigenetic Biomarker Database for Colorectal Cancer