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Epigenetic modifications in early stage lung cancer: pathogenesis, biomarkers, and early diagnosis

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机构: [1]Department of Respiratory and Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Respiratory Health and Multimorbidity West China Hospital, Sichuan University Chengdu Sichuan China. [2]Institute of Respiratory Health, Frontiers Science Center for Disease-Related Molecular Network West China Hospital, Sichuan University Chengdu Sichuan China. [3]Precision Medicine Center, Precision Medicine Key Laboratory of Sichuan Province West China Hospital, Sichuan University Chengdu Sichuan China. [4]The Research Units of West China, Chinese Academy of Medical Sciences West China Hospital Chengdu Sichuan China.
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关键词: DNA methylation epigenetics histone modification lung cancer noncoding RNA regulation

摘要:
The integration of liquid biopsy with epigenetic markers offers significant potential for early lung cancer detection and personalized treatment. Epigenetic alterations, including DNA methylation, histone modifications, and noncoding RNA changes, often precede genetic mutations and are critical in cancer progression. In this study, we explore how liquid biopsy, combined with epigenetic markers, can provide early detection of lung cancer, potentially predicting onset up to 4 years before clinical diagnosis. We discuss the challenges of targeting epigenetic regulators, which could disrupt cellular balance if overexploited, and the need for maintaining key gene expressions in therapeutic applications. This review highlights the promise and challenges of using liquid biopsy and epigenetic markers for early-stage lung cancer diagnosis, with a focus on optimizing treatment strategies for personalized and precision medicine.© 2025 The Author(s). MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.

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最新[2023]版:
大类 | 3 区 医学
小类 | 3 区 医学:研究与实验
第一作者:
第一作者机构: [1]Department of Respiratory and Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Respiratory Health and Multimorbidity West China Hospital, Sichuan University Chengdu Sichuan China. [2]Institute of Respiratory Health, Frontiers Science Center for Disease-Related Molecular Network West China Hospital, Sichuan University Chengdu Sichuan China.
通讯作者:
通讯机构: [1]Department of Respiratory and Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Respiratory Health and Multimorbidity West China Hospital, Sichuan University Chengdu Sichuan China. [2]Institute of Respiratory Health, Frontiers Science Center for Disease-Related Molecular Network West China Hospital, Sichuan University Chengdu Sichuan China. [3]Precision Medicine Center, Precision Medicine Key Laboratory of Sichuan Province West China Hospital, Sichuan University Chengdu Sichuan China. [4]The Research Units of West China, Chinese Academy of Medical Sciences West China Hospital Chengdu Sichuan China.
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