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Management of triple-negative breast cancer by natural compounds through different mechanistic pathways

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机构： [1]Department of Pharmacology, Dadasaheb Balpande College of Pharmacy, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, India. [2]Department of Pharmaceutics, Dadasaheb Balpande College of Pharmacy, Nagpur, Maharashtra, India. [3]Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia. [4]Department of KuliyateTib, National Institute of Unani Medicine, Bengaluru, India. [5]King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia. [6]Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia. [7]Center for High Altitude Medicine, Institutes for Systems Genetics, West China School of Nursing, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China. [8]Department of Pharmacy, Faculty of Health and Life Sciences, Daffodil International University, Birulia, Bangladesh. [9]Centre for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India. [10]Enzymoics, Hebersham, NSW, Australia [11] Novel Global Community Educational Foundation, Hebersham, NSW, Australia.

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关键词： DNA methylation genes histone modification natural drugs TNBC epigenetic mechanims

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Triple-negative breast cancer (TNBC) is the most severe form of breast cancer, characterized by the loss of estrogen, progesterone, and human epidermal growth factor receptors. It is caused by various genetic and epigenetic factors, resulting in poor prognosis. Epigenetic changes, such as DNA methylation and histone modification, are the leading mechanisms responsible for TNBC progression and metastasis. This review comprehensively covers the various subtypes of TNBC and their epigenetic causes. In addition, the genetic association of TNBC with all significant genes and signaling pathways linked to the progression of this form of cancer has been enlisted. Furthermore, the possible uses of natural compounds through different mechanistic pathways have also been discussed in detail for the successful management of TNBC.Copyright © 2024 Kaleem, Thool, Dumore, Abdulrahman, Ahmad, Almostadi, Alhashmi, Kamal and Tabrez.

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大类 | 3 区生物学

小类 | 3 区遗传学

第一作者：

第一作者机构： [1]Department of Pharmacology, Dadasaheb Balpande College of Pharmacy, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, India.

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通讯机构： [5]King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia. [6]Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.

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