个人中心| | 帮助
高级检索
当前位置： 首页 > 详情页

pH-Sensitive nanoparticles based on amphiphilic imidazole/cholesterol modified hydroxyethyl starch for tumor chemotherapy.

| 认领 | 导出 | |

文献详情

资源类型：
Pubmed体系：
作者：
Xu Zhilang[1] ; Yang Die[1] ; Long Tao[1] ; Yuan Lun[1] ; Qiu Shi[2] ; Li Defu[1] ; Mu Changdao[1] ; Ge Liming[1,*1] ;
机构： [1]Department of Pharmaceutics and Bioengineering, School of Chemical Engineering, Sichuan University, Chengdu 610065, PR China. [2]Department of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610065, PR China.
出处：
DOI： 10.1016/j.carbpol.2021.118827
ISSN：

关键词： Amphipathic polymer Nanocarrier pH-response Drug delivery Antitumor activity

摘要：
pH-Responsive nanoparticles (NPs) have emerged as an effective antitumor drug delivery system, promoting the drugs accumulation in the tumor and selectively releasing drugs in tumoral acidic microenvironment. Herein, we developed a new amphiphilic modified hydroxyethyl starch (HES) based pH-sensitive nanocarrier of antitumor drug delivery. HES was first modified by hydrophilic imidazole and hydrophobic cholesterol to obtain an amphiphilic polymer (IHC). Then IHC can self-assemble to encapsulate doxorubicin (DOX) and form doxorubicin-loaded nanoparticles (DOX/IHC NPs), which displayed good stability for one week storage and acidic sensitive long-term sustained release of DOX. As a result, cancer cell endocytosed DOX/IHC NPs could continuously release doxorubicin into cytoplasm and nucleus to effectively kill cancer cells. Additionally, DOX/IHC NPs could be effectively enriched in the tumor tissue, showing enhanced tumor growth inhibition effect compared to free doxorubicin. Overall, our amphiphilic modified HES-based NPs possess a great potential as drug delivery system for cancer chemotherapy.Copyright © 2021 Elsevier Ltd. All rights reserved.

基金：
Sichuan Science and Technology Program (2021YJ0478), the Fundamental Research Funds for the Central Universities (2021SCU12085) and Sichuan University Postdoctoral Interdisciplinary Innovation Fund.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 化学
小类 | 1 区 应用化学 1 区 高分子科学 1 区 有机化学
最新[2023]版：
大类 | 1 区 化学
小类 | 1 区 应用化学 1 区 有机化学 1 区 高分子科学
第一作者：
第一作者机构： [1]Department of Pharmaceutics and Bioengineering, School of Chemical Engineering, Sichuan University, Chengdu 610065, PR China.
通讯作者：
通讯机构： [1]Department of Pharmaceutics and Bioengineering, School of Chemical Engineering, Sichuan University, Chengdu 610065, PR China. [*1]Sichuan University, No. 24 South Section 1, Yihuan Road, Chengdu 610065, PR China.
推荐引用方式(GB/T 7714)：
Xu Zhilang,Yang Die,Long Tao,et al.pH-Sensitive nanoparticles based on amphiphilic imidazole/cholesterol modified hydroxyethyl starch for tumor chemotherapy.[J].Carbohydrate polymers.2022,277:118827.doi:10.1016/j.carbpol.2021.118827.
APA：
Xu Zhilang,Yang Die,Long Tao,Yuan Lun,Qiu Shi...&Ge Liming.(2022).pH-Sensitive nanoparticles based on amphiphilic imidazole/cholesterol modified hydroxyethyl starch for tumor chemotherapy..Carbohydrate polymers,277,
MLA：
Xu Zhilang,et al."pH-Sensitive nanoparticles based on amphiphilic imidazole/cholesterol modified hydroxyethyl starch for tumor chemotherapy.".Carbohydrate polymers 277.(2022):118827

相关文献

[1]医院后勤精细化管理策略研究 [2]个性化目标教学在神经外科护理实习生带教中的应用 [3]纳米增强免疫比浊法和高效液相色谱法检测化疗患者5-氟尿嘧啶血药浓度的比较 [4]徒手淋巴引流对乳腺癌术后淋巴水肿的治疗效果分析 [5]护理干预在减轻妇科恶性肿瘤腹部术后疼痛中的效果 [6]心理护理对肿瘤介入治疗患者生活质量的影响 [7]某院2400张门诊中成药处方分析 [8]人文关怀在恶性肿瘤护理中的应用效果分析 [9]综合护理干预对肺癌化疗患者生活质量的影响 [10]外涂万花油对化疗性静脉炎的预防及疗效

资源点击量：46425 今日访问量：0 总访问量：3323 更新日期：2024-11-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 四川省肿瘤医院 技术支持：重庆聚合科技有限公司 地址：成都市人民南路四段55号