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Factors That Improve Chest Computed Tomography-Defined Sarcopenia Prognosis in Advanced Non-Small Cell Lung Cancer.

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资源类型：
Pubmed体系：
作者：
Yang Ming[1,2,3] * ; Tan Lingling[1] * ; Xie Lingling[4] * ; Hu Song[5] ; Liu Dan[6] ; Wang Jing[4] ; Li Weimin[7,8,9] ;
机构： [1]The Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, China, [2]Precision MedicineResearch Center, West China Hospital, Sichuan University, Chengdu, China, [3]National Clinical Research Center for Geriatrics(WCH), West China Hospital, Sichuan University, Chengdu, China, [4]West China School of Nursing, West China Hospital,Sichuan University/ Department of Oncology, Shangjin Nanfu Hospital, Sichuan University, Chengdu, China, [5]Department ofRadiology, Shangjin Nanfu Hospital, Sichuan University, Chengdu, China, [6]Population Health Sciences, German Center forNeurodegenerative Diseases (DZNE), Bonn, Germany, [7]Department of Respiratory and Critical Care Medicine, West ChinaHospital, Sichuan University, Chengdu, China, [8]Institute of Respiratory Health, Frontiers Science Center for Disease-relatedMolecular Network, West China Hospital, Sichuan University, Chengdu, China, [9]The Research Units of West China, ChineseAcademy of Medical Sciences, Chengdu, China
出处：
DOI： 10.3389/fonc.2021.754975
ISSN：

关键词： muscle wasting muscle depletion image segmentation lung cancer prognosis

摘要：
Whether muscle strength and physical performance should be components of sarcopenia remains controversial. This study evaluated the skeletal muscle index derived from computed tomography images at the 12th thoracic vertebra level (T12 SMI), handgrip strength, performance status, and their combination for predicting overall survival in patients with advanced non-small cell lung cancer.Chest computed tomography, handgrip strength measurement, and bioelectrical impedance analysis were performed. Sarcopenia was defined based on the T12 SMI alone or the T12 SMI, handgrip, and/or physical performance (i.e. Asian Working Group for Sarcopenia [AWGS]-defined sarcopenia or severe sarcopenia).Overall, 639 participants were included; 488 (76.4%) died. At baseline, 160 (25.0%), 141 (22.1%), and 42 (6.6%) patients had computed tomography-defined sarcopenia, AWGS-defined sarcopenia, and AWGS-defined severe sarcopenia, respectively. Chest computed tomography-defined sarcopenia (hazard ratio [HR], 2.00; 95% confidence interval [CI], 1.65-2.43), AWGS-defined sarcopenia (HR, 2.00; 95% CI, 1.59-2.49), and AWGS-defined severe sarcopenia (HR, 3.01; 95% CI, 2.21-4.09) were more strongly associated with poor prognosis than a performance status score ≥2 (HR, 1.37; 95% CI, 1.10-1.73).Adding handgrip strength and the performance status score to chest computed tomography-defined sarcopenia improved its prognostic ability. Oncological sarcopenia research should focus on muscle mass, strength, and function.Copyright © 2021 Yang, Tan, Xie, Hu, Liu, Wang and Li.

基金：
This research was supported by the Post-Doctor Research Project, West China Hospital, Sichuan University (2018HXBH071) and the K&D Program of Sichuan Science and Technology Department (2020YFS0573).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类 | 3 区 医学
小类 | 3 区 肿瘤学
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 肿瘤学
第一作者：
第一作者机构： [1]The Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, China, [2]Precision MedicineResearch Center, West China Hospital, Sichuan University, Chengdu, China, [3]National Clinical Research Center for Geriatrics(WCH), West China Hospital, Sichuan University, Chengdu, China,
共同第一作者：
通讯作者：
通讯机构： [1]The Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, China, [2]Precision MedicineResearch Center, West China Hospital, Sichuan University, Chengdu, China, [3]National Clinical Research Center for Geriatrics(WCH), West China Hospital, Sichuan University, Chengdu, China, [7]Department of Respiratory and Critical Care Medicine, West ChinaHospital, Sichuan University, Chengdu, China, [8]Institute of Respiratory Health, Frontiers Science Center for Disease-relatedMolecular Network, West China Hospital, Sichuan University, Chengdu, China, [9]The Research Units of West China, ChineseAcademy of Medical Sciences, Chengdu, China
推荐引用方式(GB/T 7714)：
Yang Ming,Tan Lingling,Xie Lingling,et al.Factors That Improve Chest Computed Tomography-Defined Sarcopenia Prognosis in Advanced Non-Small Cell Lung Cancer.[J].Frontiers in oncology.2021,11:754975.doi:10.3389/fonc.2021.754975.
APA：
Yang Ming,Tan Lingling,Xie Lingling,Hu Song,Liu Dan...&Li Weimin.(2021).Factors That Improve Chest Computed Tomography-Defined Sarcopenia Prognosis in Advanced Non-Small Cell Lung Cancer..Frontiers in oncology,11,
MLA：
Yang Ming,et al."Factors That Improve Chest Computed Tomography-Defined Sarcopenia Prognosis in Advanced Non-Small Cell Lung Cancer.".Frontiers in oncology 11.(2021):754975

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